JNNP: Effects of facial movement in combination with type A botulinum toxin on the health-related quality of life of facial muscle spasms in adults in Thailand: a randomized controlled cross-trial.

Type A Botulinum toxin (BTX-A) is an option for the treatment of surface muscle spasms (HFS), which has a short-term effect of about 3-4 months.
active muscle exercise immediately after injection may enhance its effectiveness.
a small randomized controlled trial (RCT) conducted in a joint study of facial exercises with abnormal facial movements and BTX-A reported no significant reduction in the severity and frequency of facial muscle spasms, but only four HFS patients were included.
, the authors conducted a pilot, randomized, cross-test to explore the effectiveness and safety of facial movements combined with BTX-A injections.
: The treatment was divided into two groups, adult facial exercise combined with BTX-A injection (treatment group A) and individual BTX-A injection (treatment group B), single center, random, cross-designed HFS patient experimental group.
recruited participants of any severity of HFS aged 18-80 who received regular BTX-A treatment every 16 weeks.
exclusion criteria are stroke, eyelid spasms, dementia, blindness, body dependence, taking anticoagulants and not being able to perform facial exercises under video guidance.
eligible participants were randomly grouped into clinical trials.
both groups were injected with Botulinum Toxin A.
facial movements include 7 minutes of active and passive facial muscle compression, which is performed immediately under the guidance of the video after injection of BTX-A.
participants are not allowed to massage, squeeze or receive acupuncture treatment.
main evaluation result was a face spasm score of 30 (HFS-30).
patients can fill out the HFS-30 form themselves.
secondary results for patients reported HFS peak hours, duration of action.
baseline HFS-30 and Samsung Medical Center (SMC) ratings at the beginning of each 16-week treatment cycle and 1 month thereer.
the effective time, adverse events (AE), and the effective time at the end of each 16-week treatment cycle 1 month after the start of each treatment cycle.
results: 42 participants were screened.
completed the study programme with 38 participants.
analysis of HFS-30 scores showed an average difference of -2.56 points (95% CI -5.47 to 0.35) and -1.79 days (95% CI -4.20 to 0.626), respectively.
sensitivity analysis, the data showed an average difference of -3.52 points (95% CI -7.04 to 0.001) on HFS-30 scores.
treatment difference for peak effects was -1.98 days (95% CI -4.88 to 0.92) and duration was 0.18 weeks (95% CI -0.65 to 1.01).
significant differences in adverse events between the treatment groups, and no participants who withdrew from facial exercise due to adverse events and the combination of BTX-A injections showed meaningful help in adult HFS patients.
Pitakpatapee Y, Soontrapa P, Suengtaworn A, et al Effect of the combined exercise with botulinum toxin A on health-related quality of life in Thai adults with hemifacial spasm: a randomised controlled pilot cross-over trial journal of Neurology, Neurosurgery and Psimsy Published Online First: 14 September 2020. doi: 10.1136/jnnp-2020-323604MedSci Original. Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not reproduced by any media, website or individual without authorization, and must be reproduced with the words "Source: Mets Medicine".
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