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JNNP: Early atypical signs and hypometabolism of insula can predict the survival rate of patients with multiple system atrophy

 Last Update: 2021-05-08
 Source: Internet
 Author: User

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Multiple system atrophy (MSA) is an adult-onset and sporadic neurological degenerative disease.

The prognosis of MSA is poor, with a reported median survival time of 6.

Diagnosis In this MSA patient cohort study, the goal is to find survival predictors in clinical and cerebral PET metabolic characteristics.

Survival curve

Early in the course of the disease (average 3 years, IQR 2-5), patients with suspected MSA diagnosed with clinical evaluation and brain PET.

Kaplan-Meier Method to Evaluate the Survival Rate of Patients with Multiple System Atrophy Treated by OH and SSRI

Including 85 patients.

In short, brain PET is a meaningful prognostic assessment, especially in the diagnosis of left insular hypometabolism.

Brain PET is a meaningful prognostic assessment, especially in the diagnosis of hypometabolism in the left insula.
In addition, SSRIs are a potential drug candidate to slow the progression of the disease.
GrimaldiS ,BoucekineM ,WitjasT GrimaldiS Grimaldi BoucekineM Boucekine Witjas T Witjas , et al bmj.
com/content/early/2021/04/22/jnnp-2020-324823" target="_blank" rel="noopener">Early atypical signs and insula hypometabolism predict survival in multiple system atrophy Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 23 April 2021.
Published Online First : doi: 10.
1136/jnnp-2020-324823 doi: leave a message here

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