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The indications for immune checkpoint inhibitors (ICI) have greatly expanded in the past few years.
Immune diabetes diagnosis
Twenty patients (13 men) suffered from neuropathy.
Rheumatoid arthritis
All patients with neuroendocrine tumors (small cell lung cancer, n=3; Merkel cell carcinoma (n=1) with neuropathy) were seropositive for tumor neural antibodies (anti-neuronuclear antibody type 1 (ANNA1, anti-Hu)).
The clinical manifestations of these non-neuroendocrine tumors with neuropathy have been reported in previous studies.
Blood vessel
Neuropathy manifestations and results
In the neuroendocrine tumor group, the frequency of wheelchair dependence was also more common (75% vs.
Sensory neuropathy and/or neuropathic gastroparesis are only seen in the neuroendocrine tumor patients in the cohort, mimicking typical paraneoplastic neurological syndrome (PNS).
Immune neuropathy with positive tumor antibodies may be caused by ICI-stimulated cross-reactive immune responses against autoantigens expressed in tumors and nerve cells, similar to the pathogenesis of PNS.
The research in this article supports that the manifestations and outcomes of neuropathy are changing, as the indications for ICI have been expanded to include tumors typically associated with PNS.
The research in this article supports that the manifestations and outcomes of neuropathy are changing, as the indications for ICI have been expanded to include tumors typically associated with PNS.
Before the start of ICI, it is important to identify the clinical features of the pre-existing paraneoplastic neuropathy and the evaluation of tumor nerve autoantibodies to avoid the irreversible deterioration of the neurological function of these patients.
ChompoopongP ,ZekeridouA ,ShellyS ChompoopongP Chompoopong Zekeridou A Zekeridou Shelly S Shelly , et al bmj.
com/content/early/2021/05/25/jnnp-2021-326369" target="_blank" rel="noopener">Comparison of immune checkpoint inhibitor-related neuropathies among patients with neuroendocrine and non-neuroendocrine tumours Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 26 May 2021.
Published Online First: doi: 10.
1136/jnnp-2021-326369 doi: Leave a message here
