JNNP: Clinical observational study of exoimmune esophysiology in patients with Louis' dementia and Alzheimer's disease.

Inflammation plays a key role in the emoticons and progression of Alzheimer's disease (AD).
, however, the second most common neurodegenerative disease in dementia, DLB, is not known.
DLB is the second most common neurodegenerative disease in dementia, accounting for 4.2%-7.5% of dementia.
, people with DLB tend to experience delays in accurate diagnosis or misdiagnose AD or Parkinson's disease (PD).
so far, no studies have been conducted using both multiple immunoanalytic analysis and fluid cytometics to detect external inflammation of DLB.
: 93 subjects (31 DLB patients, 31 AD patients and 31 healthy elderly controls) completed a neuropsychiotic test and blood collection.
T and B cell sub-groups of individual nuclear cells in outer blood were measured by a flow cytometer, and the concentration of serum cytokines was determined by multiple immunoanalysis.
AD or DLB patients were recruited from local hospitals and the Join Dementia Research Platform (JDR). All subjects were between 50 and 100 years of age and proficient in English.
and was required to meet the National Institute of Neurological and Communication Disorders and Stroke and the Alzheimer's and Related Diseases Association's international consensus diagnostic criteria for possible AD or possible DLB.
identified 27 healthy controls from JDR or patient relationships and asked Montreal to score ≥ 26.
results: The control group (average age 66.0 ±8.6 years) was younger than the two dementia groups, but there was no significant difference in age between the AD group (average 74.1±7.4 years) and the DLB group (average 73.9±7.6 years).
differences in sex, years of education and course of illness.
the AD and DLB groups showed slight impairment on cognitive tests (measured with MoCA) compared to the control group.
the DLB group and the AD group scored significantly higher than AD in MoCA score, FCSRT-IR total or free recall score, CSDD score, or NPI total score, and the DLB group scored significantly higher on the Volatility Scale (CAF) and Parkinson's syndrome (UPDRS exercise check and total score).
the relative number of auxiliary T-cells in DLB patients decreased, B-cell activity decreased, the 1st beta-positive rate of lecytocytes increased, and the concentration of serum IL-6 increased.
: DLB and AD, external inflammation changes, T-cell sub-group analysis supports DLB adaptive immune system may shift toward aging.
addition, there are signs of inflammation of serum cytokines in DLB.
found in DLB that this unique exoimmune ideologo can guide the development of immunodemarkers.
Amin J, Boche D, Clough Z, et al Perity immunophenotype in dementia with Lewy bodies and Alzheimer's disease: an observational clinical study Journal of Neurology, Neurosurgery Psython Published Online First: 23 September 2020. doi:10.1136/jnnp-2020-323603MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, pictures and audio-visual materials, copyright owned by Mace Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
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