Jneurosci: scavenging macrophages in aging neurons may delay aging
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Last Update: 2018-05-04
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Source: Internet
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Author: User
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May 4, 2018 / BIOON / - according to a new study published in jneurosci, immune cells may cause aging and motor problems by promoting neuron degeneration In mice, inhibition of a receptor necessary for the survival of these immune cells can improve the structure of neurons and enhance muscle strength Photo source: Rudolf Martini as people live longer and longer, reducing the impact of aging on quality of life is becoming more and more important In the elderly, the neurons connecting the brain and spinal cord usually degenerate, resulting in additional hand and foot pain Rudolf Martini and colleagues found that age-related damage to the myelin and axons of the aged mice and humans was similar Compared with 12 and 18 month old rats, the number of macrophages in the bone nerves of 24 month old rats is three times that of the former Macrophages are immune cells responsible for phagocytosis of damaged and aging cells in the body A cytokine receptor inhibitor developed by plexxikon Inc, which can lead to macrophage death, has successfully reduced the number of macrophages in the bone nerve by 70%, and restored the maximum strength of the hind limbs of the aged mice to the level of 12-month-old mice Reference: Rudolf Martini et al Macrophage deplexion ameliorates peripheral neuropathy in aging mice Jneurosci (2018) Doi: 10.1523/jneurosci.3030-17.2018
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