JMRI: The coexistence of hypertension and cerebrovascular disease is related to the existence of WMH

White matter hyperintensity lesions are considered to be the core changes in Alzheimer's disease, which will accelerate the pattern of brain atrophy in areas related to Alzheimer's dementia
.

Among the vascular risk factors, chronic hypertension is one of the most important risk factors leading to the cerebrovascular pathology of WMH

White matter hyperintensity lesions are considered to be the core changes in Alzheimer's disease, which will accelerate the pattern of brain atrophy in areas related to Alzheimer's dementia

Studies have found that hypertension is related to cerebral arterial disease, including the sparseness of small arteries and hardening of large arteries

Included in the analysis of 863 (54.
2%) subjects without clinical evidence of neurological diseases
.

According to TOF MRA images, the morphological measurement of cerebral blood vessels is quantified, including blood vessel density, radius, degree of curvature and number of branches

Included in the analysis of 863 (54.

The proportion of small blood vessels decreases with increasing blood pressure
.

The proportion of small blood vessels decreases with increasing blood pressure
.

Hypertension, especially diastolic blood pressure, is significantly related to the decrease of cerebral blood vessel density (β=-104) and the decrease of branch number (β=-0.
02)
.

Decreased cerebrovascular curvature (β=1.

Hypertension, especially diastolic blood pressure, is significantly related to the decrease of cerebral blood vessel density (β=-104) and the decrease of branch number (β=-0.

The adjusted white matter hyperintensity lesion volume (WMHV) and white matter hyperintensity count (WMHC) are related to systolic blood pressure (SBP) and diastolic blood pressure (DBP)
.

The adjusted white matter hyperintensity lesion volume (WMHV) and white matter hyperintensity count (WMHC) are related to systolic blood pressure (SBP) and diastolic blood pressure (DBP)
.

WMHV and WMHC increase and blood vessel density decrease (volume: β=-2 4, count: β=-127), curvature decrease (volume: β=-0.
0 8, count: β=-0.
53) and radius increase (volume: β=-0.
08, count: β=-0.
53) : Β=12.
6, count: β=86.
6) are relevant
.

Path analysis showed that there is an association between hypertension and WMH, and this association is mediated by changes in cerebrovascular morphology

WMHV and WMHC increase and blood vessel density decrease (volume: β=-2 4, count: β=-127), curvature decrease (volume: β=-0.

In summary, the structural changes of cerebral blood vessels caused by hypertension are related to WMH

  

MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure.
JMRI.
  

MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure.
JMRI.
   MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure.
JMRI.
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