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Jisi Yingda ERK kinase inhibitor was approved for clinical use

 Last Update: 2021-09-05
 Source: Internet
 Author: User

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On August 16, JSI Indah announced that it had received the "Clinical Trial Notice" approved and issued by the National Medical Products Administration, and its extracellular regulated kinase (ERK) inhibitor JSI-1187 capsule was approved for treatment A clinical trial of patients with advanced solid tumors with mutations in the MAPK signaling pathway

The ERK signaling pathway plays a key role in tumorigenesis and the regulation of key cell processes such as cell cycle progression, cell proliferation, migration, survival, differentiation, aging, metabolism, protein synthesis and angiogenesis

In addition, abnormal activation of the ERK pathway is also common in the secondary resistance of BRAF, MEK, KRAS, ALK, CDK4/6, TRKA and EGFR inhibitors that have been marketed

JSI-1187 is an oral, highly selective ERK1 and ERK2 small molecule kinase inhibitor independently developed by JSI.

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