JID: Researchers find new ways to treat eczema

June 12, 2020 /PRNewswire/ --- Researchers at the University of British Columbia (UBC) and the Vancouver Coastal Health Institute (VCHRI) have identified a key enzyme that causes eczema that could lead to better treatmentsThe study was recently published in the journal Journal of Journal of Journalofer DermatologyEczema, also known as amethylyderitis (AD), causes the skin's protective barrier to break, making it more vulnerable to external objects that can cause the skin's protective barrier to itch, become inflamed, dry and further degenerate(Photo Source:Senior author of the study, UBC Professor of Medicine, VCHRI researcher Dr David Granville, said: "The frequent symptoms of eczema make it difficult for patients to get out and work outdoorsIt is estimated that the annual economic loss in North America is more than $5.5 billion due to eczema"Granzyme B enzyme is positively correlated with the itching of eczema and the severity of the diseaseThe researchers found that Granzyme B weakened the skin barrier by cutting proteins that bind cells together, making allergens easier to penetrate"There are proteins in our skin cells that bind them together," Granville saidIn certain inflammatory diseases, such as eczema, Granzyme B secretes from cells and explains the proteins, causing the intercellular connections to weaken and the skin to become prone to inflammation and itching"The researchers found that the genetic modification of Granzyme B or the suppression of its activity with a local gel could prevent it from damaging the skin barrier and significantly reduce the severity of the diseaseGranville said: "Previous studies have shown that granzyme B levels in patients with atopic dermatitis are associated with itching levels and the severity of the disease; "Our study provides evidence that drugs targeted at Granzyme B can be used to treat eczema and other forms of dermatitis"(BioValley Bioon.com) Source: Researchers SSculpt novel for the original source of the treating eczema: Christopher TTurner et al, GRANZYME B FORS TO MILFORIN IN OXAZOLONE-HOUSE-KING SKINS THROUGH THROUGH-RHINGS E-HERIN AND FILAGGERIN Journal, 2020DOI: 10.1016/j.jid.2020.05.095