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The insula plays an integrative role in sensory, affective, emotional, cognitive, and autonomic functions in migraine, especially in migraine with aura (MA)
The Journal of Headache and Pain published a study by Cédric Gollion et al.
The study compared 21 patients with interictal migraine with 18 healthy controls (HC) and 12 patients with interictal migraine without aura (MO) with resting-state functional MRI scans
The results show
Seed-voxel analysis revealed that in the MA, the left and right anterior dorsal insula had strong functional coupling with clusters located in the upper part of the cerebellum
Regions of interest (ROI) are located on the dorsal (A), middle (B) and ventral (C) sides of the insula
Table 1.
Figure 2.
Figure 3.
Figure 4.
These functional couplings did not correlate with duration of MA, frequency of MA episodes, and time of last MA episode, and were not found in MO
The anterior insula and superior cerebellum, including the vermis VI, are components of the central autonomic nervous system (ANS) network
Original source:
Gollion, C.
https://thejournalofheadacheandpain.
