JEM: T-cells' mechanism for fighting Zika virus infection

, June 8, 2020 /PRNewswire/ -- Biogu BIOON/--- Japanese encephalitis virus is a very common mosquito-borne virus, with more than 68,000 people suffering from encephalitis each year, and a quarter of these patients dieThe mosquito-borne virus is most common in Southeast Asia and causes severe neurological damage and mental illnessthere are currently no drugs to cure Japanese encephalitis, but there is a vaccine against the Japanese encephalitis virus (JEV)in a new study published on June 5, 2020 in Journal of Experimental Medicine, scientists from the(picture:scientists from LJI showed that antibodies against JEV are "cross-reactive" and can recognize the Zika virusThe bad news is that these antibodies actually increase the risk of Zika virus infectionIn addition, studies have shown that T-cells can help mitigate this riskIn the new study,, Shresta and her colleagues extracted antibodies from mice infected with JEV or jev-inoculated volunteers and injected them into healthy miceHealthy mice were then infected with the Zika virus, and the results showed that the mice developed a more severe antibody-enhanced response that led to increased infection of cells and replicationnext, Shresta and her colleagues focused on CD8 plus T cells in mice infected with JEVThey found that CD8 plus T cells that targeted JEV could counteract the harmful effects of cross-reactive antibodies"These JEV-induced T cells do recognize and get rid of Zika virus infection," Shresta said"
in short, CD8 plus T cells can improve survival and reduce viral load in miceFuture JEV vaccine designs will require similar reactions from CD8 plus T cells to help people avoid antibody-enhancing reactions that occur after Zika virus infection (Bio Valley Bioon.com) source: T cells can counteract red matter of the disease-borne-viruses
original origin: Chen, D., et al (2020) the encephalitis virus-primed CD8 s T cells
Journal of The doi.org/10.1084/jem.20192152.