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Psoriasis is a chronic immune-mediated inflammatory disease, accounting for 2-3% of the global population.
It is clinically manifested as a series of psoriasis homologous comorbidities, which should include cognitive impairment (CI), because of this The condition is related to chronic inflammation and abnormal immune response
.
However, information about the cognitive function of patients with psoriasis is limited
During the study period from January 1, 2019 to September 30, 2019, a total of 306 patients (91 PSA patients and 205 PSO patients) entered the study, with a median age of 42.
0 years (IQR 31.
0-50.
0)
.
MCI is defined as a MoCA score of 18-25 points, and dementia is defined as <18 points
There were 38.
56% of CI patients in the study, which is higher than the previously reported Western population
.
There are several possible explanations
Secondly, the difference in the prevalence of CI may reflect to some extent the difference in ethnicity and social background between the Western population and the Chinese population
.
Finally, the patients in the cohort may be more severely ill than the patients in other studies because they were recruited from our tertiary hospitals that are known for specializing in psoriasis
The study identified several potential risk factors for cerebral infarction in patients with psoriasis, such as age and gender, similar to previously reported literature
.
Importantly, several potentially changeable risk factors have also been identified, such as education level, living arrangements, and comorbidities including hyperglycemia and hyperlipidemia
Such as age and gender, several potentially changeable risk factors, education level, living arrangements, and comorbidities including hyperglycemia and hyperlipidemia have also been identified
The deterioration of cognitive function is the continuous process of an individual from normal cognition to MCI, then to moderate and severe damage, until the development of dementia
.
Therefore, early identification of patients with MCI may provide a window of opportunity for intervention to prevent progression to dementia
The deterioration of cognitive function is the continuous process of an individual from normal cognition to MCI, then to moderate and severe impairment, until the development of dementia.
Literature source: Kuang Y, Luo Y, Yi X, Prevalence and risk factors for cognitive impairment in patients with psoriasis.
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