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Basal cell carcinoma (BCC) is one of the most common skin cancers, and its incidence is steadily increasing with changing demographics and increased UV exposure
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Surgery is the most effective treatment and is therefore considered the first-line treatment for BCC
Kimyai-Asadial et al examined 42 cases of basal cell carcinoma less than 10 mm in diameter with a primary margin of 2 mm after resection
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The authors demonstrated that histology using serial sections at 4 mm intervals identified only 44% of positive tumor margins
Breuninger et al9 showed that when the primary resection margin was 2 mm, the proportion of BCCs with incomplete resection was 48%, and when the primary resection distance was increased to 5 mm, the proportion of incomplete BCC resections decreased to 18%
.
On the face in particular, skin care surgery is clearly a priority from a cosmetic point of view
Multiple studies have shown that 3D histology plays an important role in the evaluation of cutaneous epithelial tumors, and there are prospective data on the significance of MCS in basal cell carcinoma, and it is feasible to compare this technique with serial section histology
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We present a prospective, randomized, blinded evaluation of all types and histologically confirmed basal cell carcinomas with tumors up to 30 mm in diameter
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The purpose of this study was to investigate and compare the failure rate and the number of reoperations required for the treatment of basal cell carcinoma with serial section histology and 3D histology
We compared serial section histology with 3D histology in a prospective, randomized, controlled blinded trial and analyzed 569 basal cell carcinomas of all subtypes up to 30 mm in diameter, of whom 287 in the 3D group For example, there were 282 cases in the serial section group
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Resection is performed with an adapted primary resection margin based on the location and size of the tumor
There were no differences between the two groups with respect to patient age, tumor location, tumor diameter, tumor subtype, or primary resection margins
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In the serial resection group, 21% required re-resection; 24 tumors (8.
3D histology is a useful technique to detect tumor growth at the margin of resection, but requires a high rate of re-resection
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3D histology significantly reduced the failure rate compared to serial section histology
Source: Kofler L, Breuninger H, Schreiber RH, Three-dimensional histology vs.
Kofler L, Breuninger H, Schreiber RH, Three-dimensional histology vs.
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