JCR: Bottom draw! Smart gold nanotubes stop cancer cells from developing chemotherapy resistance!
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Last Update: 2020-07-20
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Source: Internet
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Author: User
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, June 21, 2020 /PRNewswire/ --BiovalleyBIOON/-- Chemotherapy drugs are the basis for manytreatments for malignanttumorsHowever, the current chemotherapy is still far from satisfactory, mainly due to the serious side effects of chemotherapy drugs and the resistance of cancer cells, it is therefore necessary to build an ideal chemotherapy strategy to reverse resistanceresearchers at the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences have developed an intelligentnano-
system with higher efficacy and lower side effectsPhoto Source: SIAT
The study was published in journal of The Controlled Release, entitled "Smart gold nanocages for the heat-triggered drug release and breaking chemoresistance"the intelligentnano-
system is covered with gold by a thermally sensitive lipidnano-
film and amycin (DOX) (LAD) for near-infrared (NIR) triggerdrug release and chemical photothermal combination to treat breast cancer biocompatible lipid coating promotes LAD's cell intake while avoiding drug leakage during circulation more importantly, LAD exhibits a controlled photothermal transformation properties that produce mild heat under near-infrared exposure, not only triggering the release of DOX, transferring DOX from the lysosome to the nucleus of the cell, but also producing a mild thermal killer cell effect and improving the efficacy further mechanism studies show that warm heat can reverse drug resistance by lowering drug-resistant-related markers, inhibit doX excretion, improve drug sensitivity, and significantly improve anti-cancer efficiency this intelligent and versatile LAD nanoplatform has broad application prospects in the field of drug-controlled release and chemical photothermal combination therapy (BioValleyBioon.com) reference: Lintao Cai et al.
Smart gold nanocages for mild heat-triggered drug release and breakingchemodity.
2020 Journal of Controlled Release https://doi.org/10.1016/j.jconrel.2020.04.029
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