JCO: Nuts more beneficial for advanced bowel cancer patients

Surgery and adjuvant chemotherapy have indeed improved 5-year overall survival (OS) in colon cancer patients over the past few decades [1], but cancer recurrence occurs in approximately 36 percent of patients with stage III colon cancer [2,3]

Currently, models for predicting survival outcomes in patients with stage III colon cancer rely on clinical and pathological characteristics such as age, sex, node positivity, and T stage [4,5]

Recently, a research team led by Charles S.

They found that adding dietary and life>

The results could help clinicians make personalized survival predictions for patients, prompting patients to make dietary and life>

The 1,024 stage III colon cancer patients in the study in which Fuchs' team participated were drawn from the Oncology Clinical Trials Consortium's 89803 study

During a median follow-up of up to 7.

To build a more accurate predictive model, the researchers combined existing research results and incorporated the following dietary and life>

The researchers found that aspirin and COX-2 inhibitor use, coffee, nuts, dark fish, lycopene-rich vegetables, and body mass index were all significantly associated with DFS; while physical activity, nuts, dark fish, and BMI were associated with OS significantly correlated

Next, the Fuchs team evaluated the performance of the predictive model, and they found that when dietary and life>

In addition, the Fuchs team performed further external validation of both models in another adjuvant chemotherapy trial (CALGB/SWOG 80702, including 2526 patients with stage III colon cancer), and both had good identification and calibration performance

Next, Fuchs' team analyzed 5-year predicted DFS and OS rates, as well as RRs for cancer recurrence and death

The results showed that adding a good diet and life>

Conversely, adding poor diet and life>

These results suggest that maintaining a good diet and life>

Notably, the predictive models in this study did not take into account prognostic biomarkers, which warrants further investigation

Second, predictive models do not reflect recent breakthroughs in colon cancer treatment and may underestimate survival
.
In addition, the population of this study was only patients with stage III colon cancer
.

It is warranted to further evaluate whether predictive models adding dietary and life>
.

In conclusion, predictive models based on dietary and life>
.

references

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Diet- and Life>

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