JCO: Is this cancer also overdiagnosed?

Prostate-specific antigen (PSA) is an important marker for detecting prostate cancer, however PSA screening for prostate cancer (PCa) remains controversial , mainly because it is not clear whether the main benefit of reducing metastasis and cancer mortality justifies overdiagnosis , overtreatment and potential risk of treatment-related disease

Prostate-specific antigen (PSA) is an important marker for detecting prostate cancer, however PSA screening for prostate cancer (PCa) remains controversial , mainly because it is not clear whether the main benefit of reducing metastasis and cancer mortality justifies overdiagnosis , overtreatment and potential risk of treatment-related disease

A major factor contributing to overdiagnosis and overtreatment is the targeting of specific low-grade cellular changes in the prostate as cancer

The overdiagnosis epidemic is rooted in the development of histological PCa in >30% (>60% by age 80) of men over age 50, as nearly all prostates eventually develop microscopic PCa if one lives long enough.

The overdiagnosis epidemic is rooted in the development of histological PCa in >30% (>60% by age 80) of men over age 50, as nearly all prostates eventually develop microscopic PCa if one lives long enough.

Although GS6 meets the pathological criteria for cancer (invasion into the stroma), it is practically unlikely to invade adjacent local structures or metastasize without concurrent higher-grade disease (GS ≥ 7; i.

Furthermore, no matter how much time doctors spend downplaying the importance of a GS6 diagnosis or emphasizing low risk, the phrase "you have cancer" has a powerful psychological effect on most men and their families

15-year metastasis/mortality of less than 1% in GS6 patients

15-year metastasis/mortality of less than 1% in GS6 patients

Although cancer-related risks are negligible, a diagnosis of PCa is associated with an increased risk of depression and suicide, even with low-grade PCa

Although cancer-related risks are negligible, a diagnosis of PCa is associated with an increased risk of depression and suicide, even with low-grade PCa

Therefore, experts believe that removing the cancer label of GS6 will greatly improve personal and public health

references:

Low-Grade Prostate Cancer: Time to Stop Calling It Cancer.

Low-Grade Prostate Cancer: Time to Stop Calling It Cancer.
Low-Grade Prostate Cancer: Time to Stop Calling It CancerLeave

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