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Histamine is a biologically active substance that enhances the body's inflammatory and immune responses and acts as a neurotransmitter [1,2]
.
Antihistamines (AHs) are drugs that antagonize these effects by blocking or inhibiting receptors (H receptors) [3]
immune infection
The study included patients with HBV, HCV or HBV-HCV co-infection from the Taiwan Resident Health Insurance Research Database who were examined from January 1, 2006 to December 31, 2015, using the Kaplan-Meier method and Cox ratio simultaneously.
Risk regression assessed the association between AH and HCC risk
.
Results A total of 521,071 patients with HBV infection, 169,159 patients with HCV infection, and 39,016 patients with HBV-HCV co-infection were included in this study
.
Compared with patients without AHs, patients with HBV, HCV or co-infection who used AHs had a significantly lower risk of HCC, with adjusted hazard ratios of 0.
Figure 1.
Cumulative incidence of HCC correlates with cDDD in AH
(A) HBV cohort, (B) cDDD group in HBV cohort, (C) HCV cohort, (D) cDDD group in HCV cohort, (E) HBV-HCV co-infection cohort, and (F) HBV-HCV co-infection The cDDD group in the infected cohort
.
references
1.
Branco ACCC, Yoshikawa FSY, Pietrobon AJ, et al.
Role of Histamine in Modulating the Immune Response and Inflammation.
2.
3.
4.
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