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Since PTR's follow-up chemotherapy did not show a survival benefit over chemotherapy alone, PTR should no longer be considered the standard of treatment for CRC patients with asymptomatic primary tumors and synchronous non-removable metastasis.
treatment strategy remains controversial for patients with incurable advanced colorectal cancer (CRC).
the study therefore assessed the benefits of increased non-invasive primary tumor excision (PTR) for standard chemotherapy for the survival of asymptomatic primary tumors and up to 3 non-removable iv-stage CRC patients with non-removable metastatic lesions.
February 9, Journal of Clinical Oncology published an article reporting the results of this Phase III randomized control study (JCOG1007, iPACS study; UMIN identifier: UMIN000008147).
iPACS is the first RCT to study the role of PTR in metastasis CRC cancer patients.
between June 2012 and September 2019, the study included 165 patients selected and randomly assigned to receive chemotherapy alone (84 cases) or PTR-plus chemotherapy.
The study looked at the advantages of PTR combined chemotherapy over chemotherapy alone in patients with asymptomatic CRC in stage IV that could not be removed and in patients with three or fewer non-removable metastatic diseases limited to liver, lung, and distant lymph node metastasis.
120 (73%) of the 165 patients were liver metastasis, the most common non-removable metastasis.
the distribution of two groups of non-removable metastasis diseases... MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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