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JCO: A predictive model for predicting the risk of breast cancer in childhood cancer survivors who have received chest radiotherapy

 Last Update: 2021-06-04
 Source: Internet
 Author: User

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Women who received chest radiotherapy for cancer as a child have the highest risk of breast cancer in the future .

Women receiving chest radiation from cancer at an early age the future risk of breast cancer the highest risk women receiving chest radiation from cancer at an early age the future risk of breast cancer the highest risk of breast cancer

Researchers such as Moskowitz have tried to develop a model that combines treatment-related factors, family history, and reproductive factors to predict the risk of breast cancer in childhood cancer survivors who have undergone chest radiotherapy , and validated it.

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The basic analysis data comes from multiple international cohort studies: female patients who were diagnosed with cancer before the age of 21 and received chest radiotherapy and survived for 5 years.

The breast cancer risk prediction model included the current age, chest radiotherapy area, whether chest radiotherapy was performed within 1 year of menarche, anthracycline exposure, menopausal age, and breast cancer first-degree relative history .

The breast cancer risk prediction model includes the current age, chest radiotherapy area, whether chest radiotherapy has been performed within 1 year of menarche, anthracycline exposure, menopausal age, and breast cancer first-degree relative history

Predicted absolute risk of breast cancer in 10 years

The 10-year breast cancer risk estimate for 30-year-old women fluctuates from 2% to 23% (area under the curve 0.

Menopausal women over the age of 40 who have received radiotherapy within one year of menarche and have a history of breast cancer among first-degree relatives have the highest risk of breast cancer.

Child cancer survivors who have received chest radiotherapy have different risks of breast cancer.

Original source:

Moskowitz Chaya S, Ronckers Cécile M, Chou Joanne F et al.

Development and Validation of a Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Treated With Chest Radiation: A Report From the Childhood Cancer Survivor Study and the Dutch Hodgkin Late Effects and LATER Cohorts

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