JCI: How chronic stress leads to bone loss.

September 13, 2020 /--- / --- brain is the commander of the body, receiving and processing external signals and then sending instructions to peripheral bones.
but how does anxiety lead to a decrease in bone mineral density? Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences now have the answer.
they found that the central nervous circuit from the frontal to the lower pasum brain mediates chronic stress-induced bone loss through the surrounding sensory nervous system.
their study was published September 10 in the journal The Clinical Investigation.
(Photo: www.pixabay.com) found that isolation can significantly increase anxiety levels, leading to bone loss.
analysis showed that prolonged isolation increased the concentration of epinephrine and reduced bone markers in the serum.
these changes were consistent with observations of increased anxiety and decreased bone formation in the subjects.
to identify the neural mechanisms of bone loss caused by underlying chronic stress, the team used mouse models and artificially gave unpredictable chronic nerve stimuli.
found that after four to eight weeks of chronic stress, the mice showed significant anxiety behavior.
the bone density was significantly lower in the mice in the experimental group than in the control group.
results confirmed the correlation between stress anxiety and bone loss in experimental animals and provided a good animal model for subsequent neurologic analysis.
a wide range of experiments, the researchers identified groups of inhibitory neurons that express growth inhibitors in the brain nucleosis, known as the bed nucleation of the pre-brain end-of-life pattern (BNST).
these neurons are activated when animals exhibit anxious behavior and transmit "anxiety" messages to neurons in the abdominal hymenocephalus (VMH). Professor Yang Fan,
author of the study, said: "Activation of the BNST-VMH neural circuit can simultaneously induce anxiety-like behavior in mice and cause bone loss, while inhibiting the circuit can also prevent stress anxiety and bone loss."
," the researchers found, using nuclear harnesses (NTS) and glutamate-energy neurons in the sensory nervous system to regulate bone loss caused by stress.
Liping Wang, director of the Institute of Brain Cognition and Brain Disease, said:
In this study provides a new perspective for systematic study of the mechanisms by which brain stability regulates the metabolic and endocrine function of the human body under special circumstances."
"(Bioon.com) Source: How does the press press induce bone loss? Original source: Fan Yang et al, A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic-stressed bone loss, Journal of Clinical Investigation (2020). DOI: 10.1172/JCI136105.