JCEM: The gut microbiome of polycystic ovary syndrome and its relationship to metabolic symptoms

9, 2020 // -- Researchers at the University of Tartu and their collaborators from Finland and Spain studied the relationship between the gut microbiome and polycystic ovary syndrome.
their study showed that significant changes in microbes in the intestines of women with polycystic ovary syndrome were associated with their metabolic health in late reproductive stages.
polycystic ovary syndrome is a complex endocrine disease that affects 18% of women of childbearing age.
menstrual cycles in women with polycystic ovary syndrome are often irregular, with excessive male hormones and abnormal polycystic ovary patterns.
is associated with a variety of metabolic disorders, including obesity, insulin resistance and type 2 diabetes.
exact cause of polycystic ovary syndrome is not known, but it is thought to be multi-factor, in which genetic, lifestyle and gut microbiomes may play a role.
(Photo Source: www.pixabay.com) The study aims to assess whether the gut microbiome of women of advanced reproductive age is associated with polycystic ovary syndrome. "Our study included a group of women of childbearing age in the vertical queue in northern Finland in 1966, including all women of childbearing age in the two northernmost provinces of Finland in 1966," said
lead author of the paper.
" results showed no significant differences in the gut microbiome between women with polycystic ovary syndrome and healthy women in the late stages of childbirth.
, we found differences between micro-biodiversity and hormones.
, the results showed differences in microbiome characteristics in women with prediabetes polycystic ovary syndrome compared to women with normal glucose tolerance.
Although this study provides some inspiration on the causes of polycystic ovary syndrome, further studies of a larger sample set are needed in young women to shed light on the possible link between the gut microbiome, metabolites and the development of polycystic ovary syndrome."
() Source: The Gut microbiome in polycystic ovary syndrome and its association with metabolic traits Original source: Kreete Lüll et al, The Gut Microbiome in Polycystic Ovary Syndrome and its Association with Metabolic Traits, The Journal of Clinical Endocrinology and Metabolism (2020). DOI: 10.1210/clinem/dgaa848。