JCEM: Relationship between blood sugar control and cognitive function in patients with cavity gap stroke with diabetes

Cavity stroke and diabetes are risk factors for cognitive impairment.
that the alterable risk factors for cognitive impairment have a significant impact on public health.
blood sugar status as measured by glycosylated hemoglobin (A1C) may be one of the factors.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to assess the relationship between A1C and cognitive function in patients with diabetic cavity stroke.
In 942 patients with diabetic cavity gap stroke who participated in the Secondary Prevention (SPS3) trial of small cortical stroke (ClinicalTrials.gov, NCT00059306), the researchers assessed the effects of baseline and follow-up A1C on cognitive assessment screening tool (CASI) score baseline values and changes over time.
1% increase in baseline A1C, the standardized CASI z score is reduced by 0.06 (95% CI is -0.101, -0.018).
over time, the higher baseline A1C value was associated with the lowerASI z-score (interaction p=0.037).
, the A1C increased by 1%, corresponding to a decrease of 0.021 (95% CI of -0.0043, -0.038) for the follow-up period.
All of these associations remain statistically significant after correcting age, gender, education, race, depression, hypertension, hyperlipidemia, BMI, CVD, OSA, diabetic retinal disease, kidney disease, insulin use, and whiteness abnormalities.
result, this analysis of patients with cavity stroke with diabetes showed a correlation between changes in A1C and cognitive scores over time.
to determine whether better blood sugar control in this high-risk population can slow cognitive decline, intervention studies are needed.