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JCEM: Efficacy of teriparatide combined with denosumab on spinal volume BMD and stiffness in premenopausal women with idiopathic osteoporosis

 Last Update: 2022-05-13
 Source: Internet
 Author: User

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Premenopausal women with idiopathic osteoporosis have marked deficits in bone density, microarchitecture, and strength

Osteoporosis

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.

The researchers conducted an auxiliary analysis of central quantitative computed tomography scans at baseline, after teriparatide treatment, and after denosumab treatment in a randomized trial

Trabecular vBMD (25%), other vBMD parameters and stiffness (21%) were significantly increased after teriparatide treatment (all p<0.

CONCLUSIONS: Continuous treatment with teriparatide and denosumab resulted in a significant increase in bulk density and stiffness, supporting the use of this regimen in premenopausal women with idiopathic osteoporosis

Significant increases in bulk density and stiffness following continuous treatment with teriparatide and denosumab support the use of this regimen in premenopausal women with idiopathic osteoporosis

Original source:

Sanchita Agarwal, et al.

Spine volumetric BMD and strength in premenopausal idiopathic osteoporosis: Effects of teriparatide followed by

denosumab

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