JCEM: Distant metastasis of differentiated thyroid cancer in children and adolescents.

Children and adolescents with DTC are characterized by more frequent distant metastasis (DM) than adult differentiated thyroid cancer (DTC).
Recently, a study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, looked at the clinical outcomes of DM in this population and analyzed dm-related risk factors.
researchers reviewed the medical records of 171 19-year-old DTC patients who underwent surgery between 1979 and 2014.
outcome indicators for the study were clinical responses to radioactive iodine (RAI) treatment assessed in the American Thyroid Association (ATA) guidelines for adult DTC and RECIST standards.
researchers assessed risk factors associated with non-distant transfer survival (DMFS).
the researchers observed DM in 29 patients, all of whom had lung metastasis.
of lung metastasis are divided into three categories: large nosedles, micro-nosedles, and no-obvious nosedles (only detected by RAI flickering).
patients without significant nosions, patients who responded well to CR according to the ATA guidelines or RECIST standards were most often observed.
associated with DMFS include gender, clinical lymph node metastasis (LNM), thyroid dilation, and LNM numbers.
participants were divided into three groups based on the number of risk factors: low risk (no risk factors), medium risk (1 risk factor), and high risk (2 risk factors).
20-year DMFS in low, medium and high risk groups was 99.0%, 71.7% and 28.6%, respectively.
that in order to achieve the efficacy of RAI treatment, DM needs to be diagnosed early before a significant shift occurs.
DTC for children and adolescents, selective therapy will be preferable.
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