JCEM: Association between body mass index and serum uric acid and dementia.

Recent studies have shown that higher BMI and serum uric acid levels are associated with a lower risk of dementia.
, however, these negative correlations remain controversial, and it is not clear whether serum uric acid and BMI are confused.
recently, a study was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to investigate the independent association between BMI and uric acid and their interactions with dementia risk.
researchers analyzed 502,528 participants aged 37 to 73 from the UK Biolibrary who recorded BMI and uric acid levels between 2006 and 2010.
participants' dementia was determined by the use of electronic health records.
2,138 participants developed dementia during an average of 8.1 years of follow-up.
compared to normal-weight participants, underweight participants had an increased risk of developing dementia (risk ratio of 1.91, 95% confidence interval (CI: 1.24-2.97).
However, as weight gained, the risk of dementia continued to decline, with overweight and obese participants reducing their risk of dementia by 19 per cent (HR=0.81,95 per cent: 0.73-0.90) and 22 per cent (HR=0.78, 95 per cent CI: 0.68-0.88) respectively.
participants with uric acid levels in the lowest five-digit range also had a 25 percent lower risk of developing dementia (HR-0.75, 95 percent CI: 0.64-0.87).
significant interaction between BMI and uric acid and dementia (interaction P-0.004), obesity enhances the protective effect of serum uric acid on dementia risk.
result, both BMI and uric acid are independent predictors of dementia, and there is a dose-response negative association between BMI and uric acid and dementia.
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