JCB: Cancer cells can "turn enemies into friends"

Researchers have now discovered a new mechanism by which invasive breast cancer cells evade immune system metastasis or spread to other parts of the body!----this helps develop treatments that target the process, prevent or prevent breast cancer metastasis, and reduce deathpapers were published recently in the Journal of Cell Biologynatural killer cells (an immune system) can limit their metastasis by inducing them to diebut the patient's cancer cells will still metastasize, so there must be an unknown escape routeso Isaac Chan and colleagues at Johns Hopkins University in the United States studied the interactionbetween natural killer cells and invasive breast cancer cells in real time in the labfound that metastatic breast cancer cells can reprogram natural killer cells, causing them to stop killing cancer cells and instead assist ingress"This study identifies new strategies for cancer cells to woo and utilize the immune system," saidChanIf we can stop or reverse the reprogramming of natural killer cells, it could lead to a new way to stop metastasis and reduce breast cancer mortality" Our study shows that natural killer cells selectively target cells that initiate the transfer process and reveal ways in which cancer cells induce the immune system to assist themstudy also highlights the power of multidisciplinary cancer researchthe project combines experts in oncology, cell biology, immunology, and biomedical engineering to understand the mechanisms of tumor metastasis" author and johns Hopkins University professor Andrew Ewald saidusing molecular expression and computational analysis, researchers were able to map the interactions between immune cells and each suspected molecule between cancer cells and identify the interactions that may regulate cell-to-cell communicationwhen researchers block these inhibitions, natural killer cells continue to act as "good people" and constantly remove cancer cells researchers also describe in their paper a new immunotherapy strategy to reverse this reprogramming process in a mouse model of breast cancer metastasis researchers say other types of cancer may also be involved in the process immunotherapy that targets natural killer cells can also be used in combination with existing immunotherapy that stimulates T-cells to fight cancer