JBC: Scientists identify new targets for developing TB drugs that could be targeted!

July 13, 2020 // Recently, scientists from the University of Texas and other organizations have discovered a potential target for the development of a new drug for tuberculosis, in a recent study published in the international journal Journal of Biological Chemistry entitled "N alpha-Acetylation of the virul factor EsxA is saued for myco cytosositandy and virulenceence"photo source: eLife researcher Professor Jianjun Sun said: 'We have long been committed to the study of mycobacterium tuberculosis, a pathogen that causes tuberculosis (TB, tuberis diseases)tb is a global infectious disease, and researchers urgently need to develop new treatments for TBresearcher Sun has been working on the pathogenesis of tuberculosis for more than a decade, focusing on a toxicity factor called EsxA, a very important factor for the toxicity of TB, and a potential target for future scientists to develop anti-TB drugs and vaccinesin the course of infection, mycobacterium tuberculosis can be ingested by the body's immune cells, under normal circumstances, bacteria can be killed by immune cells, but mycobacterium tuberculosis releases toxic factors such as EsxA to slow the host body's immune response, the researchers found that EsxA's N alpha acetylation modification or will significantly affect the infection process of tb mycobacteriaconcluding researcher Aguilera, said the findings are critical for later scientists to develop new treatments for tuberculosis, and while there are many challenges in the study process, we believe that through further research later in the year, we will overcome difficulties and identify more potential targets for developing new treatments for tbOriginal source of: Javier Aguilera, Chitra BKarki, Lin Li, et alN-Acetylation of the virulence factor EsxA is sait for mycobcycyd cytosolic sit and virulenceJournal of Biological Chemistry(2020) doi: 10.1074/jbcRA119.012497.