JBC: Molecular mechanisms for eye circulation using vitamin A

May 11, 2020 /PRNewswire/ -- --- many people have heard of the idea that carrots are good for the eyesAlthough the specific reason may not be clearIn fact, carrots are rich in vitamin A, a nutrient necessary to maintain visionin a recent study, researchers from the University of Dublin revealed the mechanism by which the eye uses vitamin A badly(photo source:to maintain vision, the vitamin A we ingest in our diet needs to move from an inactive (insensitive to light) form to an activated (light-sensitive) formToo little or too many types of activity in vitamin A can lead to hereditary or age-related blindnessthe retina is the photosensitive layer at the back of the eye, which collects light and transmits it to the brain so that we can see the surrounding environmentIt contains the specialized cells needed to receive light, called rod cells and cone cellsrod cells are important for vision in dim light, while the cone softens work in bright light conditionsThanks to advances in modern technology, we are in bright environments day and night, so most human visual experiences depend on cone cellsstudy, the authors used a drug called Emixustat to study the recycling of cone photoreceptors on vitamin A and its effecton on bright light visionIn zebrafish models, Emixustat is used to block the activity of a protein called RPE65In the retina, this protein plays an important role in converting inactive vitamin A into active vitamin Athe genetic mutation of the RPE65 protein is related to the rapid development of hereditary childhood blindnessInsufficient levels of photosensitive vitamin A can lead to the death of rod cells and/or cone cellsThe researchers also demonstrated that the chemically synthesized vitamin A (9-cis-retinalaldehyde) can restore light to zebrafish by bypassing the abnormality of RPE65 (biovalleybioon.com) Source: StudyshowshowoureyesLittletaa
Source: Ward, R., etal 2020) -photopic and photopicsoftherincycles,'eandlate-phasesof-cone-photo-mediatedvision.
Journal of BiologicalChemistry
.doi:org/10.1074/jbc RA119.011374.