JAX Interview: Humanized Mouse Model 2.0 – Dual Antibiotic Evaluation Platform

BIT 2022 5th Realistic Antibody Drug In-depth Focus Summit will be held
in Shanghai on September 8-9.
BIT 2022 Dr.
Jieling Yang, Technical Strategy Manager of BIT 2022 5th Realistic Antibody Drug Deep Focus Summit, Jackson Aite Biotechnology (Beijing) Co.
, Ltd
Q What are the highlights of humanized mice with immune system in the development of bispecific antibody drugs? It is that all targets on these cells are human-derived and can be mainly used for pharmacodynamic and drug safety studies Mainly cytokine storm (CRS) research on the application of Q PBMC immune system humanized mouse model is one
of the animal models commonly used in dual-antibody drug research.
For the two most common problems in this type of model, GvHD and donor differences, does JAX have any suggestions or solutions? Donor differences are an unavoidable problem in humanized mice because this is a natural difference
in the population.
Q Dual antibodies based on NK cells are also at
the forefront of research and development.
The initial CD34+ humanized mouse model generally lacked NK cell subset differentiation, resulting in mouse strains
that later stabilized expression of IL-15.
Please tell us more about JAX's NSG-IL15
.
Q China's biopharmaceutical industry is developing rapidly, and the field of tumor immunity is only one of the corners
.
If you look at the industry as a whole, can you tell us about what unique disease models or resources Jackson Labs can have to support drug discovery? Our disease model can be said to cover all areas of disease research, such as neurodegenerative disease models, autoimmune disease models, rare disease models, and so on
。 In addition, in order to better serve Chinese users, JAX has also set up a joint venture subsidiary In China, JAX has also set up a joint venture subsidiary Jackson Aite Biotechnology Co.
, Ltd.
in China, in addition to helping everyone more conveniently obtain imported JAX mice, Jackson Aite will also produce high-quality JAX mice locally, covering common inbred mice, severe immunodeficiency strainSGTM and humanized mouse strains.
It is hoped that Chinese users can obtain high-quality mouse models
in a more convenient and economical way.