Japanese scientists discover 8 genes linked to chromosomal number abnormalities

Japanese scientists reportedtuesdaythat they found eight genes associated with abnormal chromosome numbers in bread yeastBecause similar genes exist in the human body, the results may help study theofdiseases such as miscarriage and Down syndrome caused by abnormal lysy chromosomenumbersThere are2
3 pairs of human chromosomes, 46 pairsForty-six chromosomes are distributed evenly among the resulting sperm or eggs by subtracting division, and after fertilization, the number of chromosomes is restored to 46About 95% of people with Down syndrome are caused by "
2
1 three bodies", i.ein the process of egg cell reduction division, a2chromosome 1 is not separated, increasing theof fertilized eggs to 2 chromosome 1 to 3, rather than the normal two Abortion is also due to abnormal number of chromosomes in many cases Homologous chromosomal pairing and gene recombination occur in subtracted divisions, and previous studies have found that without genetic recombination, chromosomes cannot be properly separated, resulting in abnormal numbers of sperm and egg chromosomes Harajug, a professor at the Institute of Protein Studies at Osaka University in Japan, and other researchers wrote in the online edition of the journal Nature Genetics on Friday
that they the of bread yeast, which has abnormal chromosome numbers and cannot produce spore (
equivalent to sperm or egg), study their genetic condition The researchers found that the of the eight genes associated with chromosomal abnormalities in these bread yeasts, that any of them have problems , the probability of yeast chromosome genes failing to recombine increased They also found that the proteins synthesized by the eight genes bind together into a complex, and that the number of yeast chromosomes that do not form the complex is also skewed The researchers speculate that this protein complex ensures that the recombination of chromosome genes goes smoothly, and that if it can be confirmed that human abortion is caused by the decline in the function of the complex, it will help diagnose and treat the related diseases