Japanese research found that the main culprit of chronic cancer pain -- protein "HMGB1"
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Last Update: 2013-08-23
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Source: Internet
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Author: User
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People's daily news on August 22: according to the news of Japan's kyodo.com, a scientific research team composed of Professor of pharmacology of Graduate School of Hiroshima University in Japan, such as Yoshio Nakata, was published in PLoS on August 22 According to research results published in one, protein HMGB1, an inflammatory substance related to rheumatism, is one of the main culprits in chronic pain accompanied by advanced cancer, diabetes and neuralgia This result was found by the above research team and the Graduate School of Okayama University It has been confirmed that chronic pain, which is difficult for existing analgesics to work on the market, such as morphine, can be inhibited after using the antibody of HMGB1 "We look forward to this finding contributing to the development of new therapeutic drugs," the team said According to Professor Zhong Tian, in the experiment of binding the sciatic nerve in the waist of experimental rats to produce chronic pain, HMGB1 in the spinal cord nerve cells increased from the third day, and began to appear pain symptoms Later, the pain continued, proving that HMGB1 did participate in it In the 21 day chronic period after the start of the experiment, the administration of HMGB1 antibody to the experimental rats can reduce the pain, but even in the third day of the acute pain period, there is almost no relief effect.
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