JAMA Surg: Cyan green lung targeted inhalation vs intravenous injection for lung cancer tumor edge identification

The recognition of tumor edges in surgery is very important for tumor removal, and intravenous indigoma (ICG) has some limitations in lung cancer excisionRecently, researchers examined the clinical application value of an ICG inhalation technique for the display of lung tumor edge displaysin the mouse and rabbit lung tumor model, the distribution of inhaled ICG in the outer lung tumor edge of the body was studied by using near-infrared imaging systemThe effect of ICG inhalation of lung tumor edge detection was evaluated by comparison with intravenous method (n-32, 4 mice per time)Based on preclinical data, the researchers also assessed the use of ICG inhalation to help detect tumor edges in lung cancer patients .n.610min to 24h after inhalation of ICG, the distribution of ICG in the lungs is significantly higher than that of other organs (pulmonary signal-to-noise ratio: 39486.4)In vitro histological analysis showed that in both lung tumor models, ICG inhalation was observed in healthy lung tissue, but rarely found in tumor tissueThe difference in fluorescence signals in normal lung tissue and tumor lung tissue was caused by mechanical airway obstruction caused by tumors and differences in the intake of alveveve veto macrophages in normal tissue after inhalation of ICGInhalation at 20 times low-dose ICG, tumor edge detection is 2 times more efficient than intravenous injection (2.9)studies have shown that it is feasible to dose the drug with the targeted inhalation of the anti-cyan green lung, and that the effect of anti-cymtod lung targeted inhalation in clinical surgery is better than that of intravenous injection