JAMA Sub-Journal: Garlic Supplement Anti-Gastric Cancer Effect Seine No! Data from 22 years of follow-up in Shandong showed that drinking alcohol offsets the benefits of garlic, and that smoking is associated with a 101 percent increased risk of death from stomach cancer.

In September last year, researchers from Peking University Cancer Hospital published a research paper with a follow-up time of 22.3 years in the famous medical journal BMJ.the researchers found that the three methods of eradication of Helicobacter pylori, vitamin supplements and garlic supplements can effectively reduce the risk of gastric cancer death by 38%, 52% and 34%, respectively.recently, researchers from Peking University Cancer Hospital conducted a secondary analysis of the above data. They found that smoking was associated with a 72% increase in the incidence of gastric cancer and a 101% increase in the mortality rate, and this correlation was more significant in patients with positive Helicobacter pylori.however, smoking had no effect on the anti-cancer effect of vitamin supplements and garlic supplements.in addition, there was no significant correlation between alcohol consumption and the occurrence and death of gastric cancer.however, drinking alcohol can counteract the anti-cancer effect of garlic supplements.the researchers believe that their research results provide evidence for the association between lifestyle and gastric cancer in high-risk groups, and suggest that large-scale gastric cancer prevention strategies should be targeted at specific populations to maximize the potential beneficial effects of prevention strategies.related research results were published on JAMA netw open [2].} the screenshot of the first page of the paper shows that gastric cancer is the third leading cause of cancer death in the world [3].Linqu County in Shandong Province is one of the areas with the highest mortality rate of gastric cancer in the world [4].it is estimated that between 1980 and 1982, 55 or 19 people died of gastric cancer for every 100000 men or women [5].the high mortality rate of gastric cancer in Linqu is closely related to the local eating habits.local staple acid pancakes often contain the carcinogen aflatoxin, which leads to a 30% increase in the risk of gastric cancer [5].in addition, people in Linqu are generally lack of selenium and vitamin C.and the deficiency of these two nutrients is also related to the high risk of gastric cancer [6,7].in 1995, one year after Helicobacter pylori was listed as a grade 1 carcinogen by who [7], researchers tested the preventive effect of vitamin supplements and garlic supplements, as well as radical eradication of Helicobacter pylori, on gastric cancer in Linqu.finally, a total of 3365 people participated in the prospective clinical trial. Among them, 2258 H. pylori positive participants were assigned to receive 2-week eradication of Helicobacter pylori, 7.3-year vitamin supplement and / or 7.3-year garlic supplement, respectively. the remaining 1107 Helicobacter pylori negative participants received the same vitamin and / or garlic supplement respectively. Br / > < 22 years of follow-up, a total of patients with gastric cancer were diagnosed as gastric cancer. has shown good results in preventing gastric cancer, eradication of Helicobacter pylori and vitamin supplements, but garlic supplements have not significantly reduced the incidence rate of gastric cancer. however, all three methods significantly reduced the mortality rate of gastric cancer. Radical eradication of Helicobacter pylori, vitamin supplements and garlic supplements reduced the risk of gastric cancer death by 38%, 52% and 34%, respectively. this suggests that lifestyle intervention may be a potential primary prevention measure for gastric cancer. } the relationship between the three treatments and gastric cancer death seems to be clear, but the researchers still think it is not accurate enough. because some studies have reported that smoking, drinking and other living habits are also related to the occurrence of gastric cancer, it is necessary to explore the impact of lifestyle such as smoking and drinking on the prevention of gastric cancer and the reduction of mortality of gastric cancer patients with vitamin and garlic supplements. only in this way can we more accurately determine the appropriate population for intervention, so as to achieve the optimal effect. therefore, there is a second analysis. researchers first analyzed the relationship between smoking, alcohol consumption and major dietary factors and the cumulative incidence rate and mortality of gastric cancer. Then, in these groups of lifestyle factors, we studied the relationship between vitamin and garlic supplements and the incidence rate and mortality of gastric cancer. analyzed the main data of each subgroup for two times. It is not difficult to see that the smoking is associated with an increase of 72% incidence rate of gastric cancer and a 101% increase in mortality. if smoking was considered only in Helicobacter pylori positive group, smoking and gastric cancer incidence rate and mortality rate increased by 88% and 115% respectively. however, no significant association was found between alcohol consumption and other main dietary habits and the incidence rate and mortality of gastric cancer, even from the perspective of Helicobacter pylori. in subgroup analysis, researchers found that smoking or other dietary factors had no significant effect on the relationship between vitamin and garlic supplements and the incidence rate and mortality of gastric cancer. however, alcohol consumption was an exception. Garlic supplements did not reduce the risk of death from gastric cancer for people with a history of drinking (HR, 0.92), while for those without drinking history, garlic supplements significantly reduced the risk of death from gastric cancer (HR, 0.33). and this phenomenon is more significant in Helicobacter pylori infected population. } the relationship between alcohol consumption and garlic supplements in preventing gastric cancer. In short, alcohol consumption can offset the benefits of garlic supplements in reducing mortality caused by gastric cancer. researchers have also speculated on the reasons behind this phenomenon, which may be that garlic supplements can inhibit the risk of DNA mutation [9], while alcohol increases the risk [10]. although this study did not find a correlation between alcohol consumption and the incidence of gastric cancer, the effect of garlic supplementation on gastric cancer mortality was particularly significant in non drinkers, suggesting that alcohol consumption may alter the effect of garlic supplements. however, the sample size of this study is small, the detailed lifestyle related data of participants are lacking, and the research objects are high-risk groups, so there are certain limitations. , in general, the researchers believe that smoking is associated with increased incidence rate and mortality of gastric cancer patients based on their research data. Alcohol intake may counteract the effect of garlic supplements on reducing mortality in patients with gastric cancer. of course, you can still think of this as an article that advises you to quit smoking and drinking. if you don't want to quit, you can't be helped by any supplements that are effective. although ASCO in 2020 is over, its impact on cancer treatment in the next few years is just beginning. in order to help you quickly grasp the key points of this year's ASCO and effectively obtain a panoramic understanding of the frontier progress, we have also made full efforts to create the "asco2020 trend interpretation". it comprehensively combs the 9 major cancer species and the key academic research in 300 oral reports, so as to give you a comprehensive overview of the progress of ASCO in 90 minutes.