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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: The United States has reported the first case of severe allergic reaction to the Pfizer new crown vaccine, and claimed that people who had a severe allergic reaction to the first shot of the new crown vaccine should no longer Get the second shot
.
Recently, a study published in the journal "JAMA Network Open" showed that 22 potential allergic reactions to 38895 doses of mRNA-based COVID-19 vaccine were analyzed, and it was found that they may be sensitive to PEG before vaccination, and the mRNA itself did not cause allergies.
Response
.
Individuals who respond to the first dose of the vaccine can safely receive the second dose under medical supervision
.
According to reports, the United States has experienced the first severe allergic reaction to the Pfizer new crown vaccine
.
Two medical staff in the same hospital in Alaska received first aid after being vaccinated with Pfizer's new crown vaccine
.
A medical worker who injected the Pfizer vaccine at the Barrett Regional Hospital developed severe allergies 10 minutes after the vaccination, a rash on his face and body, shortness of breath and a rapid heartbeat
.
The director of the emergency department of the hospital stated that the person received standard allergy treatment, but his symptoms repeated and he was sent to the intensive care unit for observation
.
The second medical staff who received first aid received the injection on the 16th.
Ten minutes after the vaccination, symptoms such as ocular swelling, dizziness and itchy throat appeared
.
He was then sent to the emergency room for treatment
.
However, the hospital stated that his symptoms were not allergies and he was allowed to be discharged within 1 hour.
.
As of the evening of the 16th, this hospital has received 144 doses of Pfizer vaccine
.
Anne Zink, chief medical officer of Alaska, said that there are no plans to change the vaccination plan at this time
.
Although the Pfizer vaccine has proven to be safe in clinical trials involving 44,000 people, with an effective rate of about 95%, the Alaska case may exacerbate concerns about possible side effects
.
Experts say that these issues may prompt people to demand stricter guidelines to ensure careful monitoring of adverse reactions
.
(Source: New York Times) The CDC in the United States once stated in a new crown vaccination guidance that people who have a severe allergic reaction to the first shot of the new crown vaccine should not receive a second shot
.
The CDC also stated that after the first batch of new crown vaccines were sent to all states in the United States on the 13th, 272,000 people have been vaccinated across the United States, and 6 people developed severe allergic reactions during the observation period and received timely treatment
.
In response to the public's concern about whether people with a history of allergies can be vaccinated with the new crown vaccine, Wang Huaqing, chief expert of the China Centers for Disease Control and Prevention's immunization program, responded to popular science at the press conference of the Joint Prevention and Control Mechanism of the State Council on September 7, 2021
.
He said: "Regarding the contraindications of vaccination allergies, the "New Coronary Vaccination Technical Guidelines" stipulates two points.
One is allergic to vaccine components; the other is severe allergic reactions to the new crown vaccine in the past
.
There are two kinds of allergies.
It is not possible to get vaccinated
.
People
who have food allergies, drug allergies, cosmetics allergies, and mite allergies can usually be vaccinated
.
” He also said: “It is suspected that allergies are related to vaccination.
Need to determine whether it is a general reaction or an abnormal reaction
.
Every place has a vaccination abnormal response investigation and diagnosis expert group and a vaccination abnormal response identification group, which will make comprehensive judgments based on the characteristics of the vaccine, the clinical manifestations and past history of the recipient, the diagnosis and treatment process, and the vaccination situation, etc.
, to determine whether it is correct or not Allergic reactions caused by vaccination
.
"Regarding the issue of allergies to the new crown vaccine, a recent study by the Stanford University School of Medicine showed that allergic reactions to the new mRNA-based new crown vaccine are rare, usually mild and treatable, and they should not stop people.
vaccination
.
the results of the study on September 17 published in "JAMA Network Open" magazine
.
senior author of the study, NADDISY Foundation pediatric food allergy, and immunology professor, asthma Kari Nadeau, MD, said: "we want to Know the allergens of the new vaccines and understand the causes of them
.
"This study analyzed the 22 potential allergic reactions of the first batch of 39,000 doses of Pfizer and Moderna's new crown vaccine received by the Stanford University health care institution shortly after receiving the emergency use authorization of the U.
S.
Food and Drug Administration (FDA)
.
Most people who responded in the study were allergic to components that help stabilize the new crown vaccine; they did not show allergies to vaccine components that are immune to the SARS-CoV-2 virus
.
In addition, these allergic reactions occur through indirect activation of allergic pathways, which It makes them easier to alleviate than many allergic reactions
.
Nadeau, director of the Sean Parker Center for Allergy and Asthma Research at Stanford University, said: "It's nice to know that these reactions are manageable
.
Allergic reactions to these new vaccines are rare.
If it does happen, there are ways to control it
.
"The lead author of the study is a former postdoctoral scholar, Dr.
Christopher Warren, who is now an assistant professor at Northwestern University's Feinberg School of Medicine
.
Nadeau also said that this study also proposes how vaccine manufacturers can reformulate vaccines to reduce allergic reactions.
Possibility
.
Delivery of protein manufacturing instructions .
The new coronavirus vaccine based on mRNA provides immunity through small fragments of mRNA, which encodes the molecular instructions for protein production
.
Because the mRNA in the vaccine is fragile, it is wrapped in lipids (fatty substances) and sugars.
bubbles in order to maintain stability
.
when the vaccine is injected into a person's arm, mRNA can enter the nearby muscles and immune cells, then produce non-infectious protein similar to SARS-CoV-2 surface of the virus
.
these proteins trigger the immune Reactions enable the human immune system to recognize and resist the virus
.
According to the Federal Vaccine Adverse Event Reporting System, the estimated incidence of severe vaccine-related allergic reactions (severe allergic reactions requiring hospitalization) for Pfizer and Moderna vaccines is per 100 Ten thousand doses of 4.
7 cases and 2.
5 cases
.
However, the federal system did not capture all allergic reactions to the vaccine, and often ignored those mild or moderate allergic reactions
.
In order to fully understand how common the allergic reactions of the new vaccine are, and How serious, the research team checked the medical records of medical workers: between December 18, 2020 and January 26, 2021, they received 38895 doses of mRNA-based COVID-19 vaccine at Stanford Medical School
.
These vaccinations included 31635.
Pfizer vaccine and 7260 doses of Moderna vaccine
.
Researchers searched the medical records of allergic reactions of vaccinators and determined which reactions were related to the vaccine
.
Twenty-two subjects, 20 of whom were women, may have allergic reactions, which means that specific symptoms began to appear within 3 hours of receiving the injection
.
Researchers looked for the following symptoms in the recipient’s medical records: hives; swelling of the mouth, lips, tongue, or throat; shortness of breath, wheezing, or chest tightness; or changes in blood pressure or loss of consciousness
.
Only 17 of 22 subjects met the diagnostic criteria for anaphylaxis
.
Three subjects received adrenaline therapy, usually for stronger allergic reactions
.
All 22 people recovered
.
Among the 22 subjects, 15 had a history of allergic reactions recorded by a doctor, including 10 allergic to antibiotics, 9 allergic to food, and 8 allergic to non-antibiotic drugs
.
(Some recipients have more than one type of allergy
.
) The researchers performed follow-up laboratory tests on 11 people to determine what type of allergic reaction they had and what triggered their allergy: the inertia in the foam Sugar or lipid components, or other components in the vaccine? Study participants underwent a skin prick test in which clinicians injected small amounts of potential allergens-lipids, sugars (polyethylene glycol or polysorbate) or whole vaccines into the skin
.
The skin prick test can detect allergic reactions mediated by an antibody called immunoglobulin E (IgE); these reactions are usually associated with the most severe allergies
.
In the skin prick test, no subject reacted to the inert ingredients in the vaccine, and only one subject's skin reacted to the entire new crown vaccine
.
Subsequent blood tests showed that the vaccinators did not have significant levels of IgE antibodies against the vaccine components
.
Since the skin test cannot explain the mechanism of the receptor's allergic reaction, the researchers proceeded to another diagnostic test
.
Vaccine recipients provided blood samples to test for allergic activation of immune cells called basophils
.
The blood samples of 10 of the 11 participants showed a reaction to polyethylene glycol (PEG), an inert ingredient used in the Pfizer and Moderna vaccines
.
In addition, when the entire mRNA vaccine was mixed with their own basophils, the basophils of all 11 subjects were activated
.
The blood of all 11 subjects contained high levels of anti-PEG IgG antibodies; IgG antibodies in some cases helped to activate basophils.
This finding suggests that these individuals may be susceptible to PEG prior to vaccination.
Sensitive
.
Nadeau said: "It seems that the mRNA itself does not cause allergic reactions
.
" In addition, data shows that the reaction to the new crown vaccine is usually not the most serious allergic reaction, which is good news in terms of vaccine safety
.
Allergic reactions mediated by IgG and basophils can be controlled with antihistamines, fluids, corticosteroids, and close observation, which means that many individuals who respond to the first dose of the vaccine can be safely under medical supervision To receive the second dose of vaccine
.
PEG is widely used as a stabilizer for household products, cosmetics and medicines, and women are more likely to be exposed to large amounts of this substance, which may explain why more vaccine allergies appear among women
.
(Repeated exposure to a substance can sometimes sensitize the immune system and cause allergies
.
) Nadeau said: "Since most of the reactions are to polyethylene glycol PEG rather than the active ingredient of the vaccine, it is very likely that vaccine manufacturers will reformulate the vaccine with different stabilizers, and these stabilizers are unlikely to cause allergies.
.
"references: https: //medicalxpress.
com/news/2021-09-allergies-mrna-based-covid-vaccines-rare.
html Note: This article is intended to introduce the progress of medical research, treatment programs can not be used as a reference
.
If you need health guidance, please go to a regular hospital
.
Popular·Article Gene Sequencing [Nature Sub-Journal] The largest DNAm gene research to date: Research on genetic variant tumors related to DNAm at 420,509 DNAm sites in the blood has been identified [Heavyweight] Scientists at Johns Hopkins University The discovery that the self-correction function of genes can resist blood cancer is expected to be a major breakthrough in the treatment of blood cancer! Genetic testing [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
The new coronavirus [Nature] is a heavyweight! Why can the delta mutant virus spread so quickly and fiercely? Scientists from the University of Cambridge will take you to understand its obesity and health [The Lancet] Be alert! After more than 9 million BMI measurements of more than 2 million people, it is found that young people aged 18 to 24 are at the highest risk of being overweight or obese in the next ten years.
New coronavirus [Nature] The world's first needle-free DNA new coronavirus vaccine is about to be used first in India! According to a survey of 28,000 people, its effectiveness is 67%, and it can even prevent Delta vaccine research [Cell] Have you been vaccinated against HPV? Scientists at Johns Hopkins University have discovered that if they are vaccinated while young, they will be protected from throat cancer and cervical cancer after 25 years.
Intestinal health [Research] "Universal" intestinal microbiota: 40,000 data confirm that antibiotics cause Recommendations for the direct causes of cancer·Activities The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
Please indicate the source for reprinting.
Author: Daisy Guide: The United States has reported the first case of severe allergic reaction to the Pfizer new crown vaccine, and claimed that people who had a severe allergic reaction to the first shot of the new crown vaccine should no longer Get the second shot
.
Recently, a study published in the journal "JAMA Network Open" showed that 22 potential allergic reactions to 38895 doses of mRNA-based COVID-19 vaccine were analyzed, and it was found that they may be sensitive to PEG before vaccination, and the mRNA itself did not cause allergies.
Response
.
Individuals who respond to the first dose of the vaccine can safely receive the second dose under medical supervision
.
According to reports, the United States has experienced the first severe allergic reaction to the Pfizer new crown vaccine
.
Two medical staff in the same hospital in Alaska received first aid after being vaccinated with Pfizer's new crown vaccine
.
A medical worker who injected the Pfizer vaccine at the Barrett Regional Hospital developed severe allergies 10 minutes after the vaccination, a rash on his face and body, shortness of breath and a rapid heartbeat
.
The director of the emergency department of the hospital stated that the person received standard allergy treatment, but his symptoms repeated and he was sent to the intensive care unit for observation
.
The second medical staff who received first aid received the injection on the 16th.
Ten minutes after the vaccination, symptoms such as ocular swelling, dizziness and itchy throat appeared
.
He was then sent to the emergency room for treatment
.
However, the hospital stated that his symptoms were not allergies and he was allowed to be discharged within 1 hour.
.
As of the evening of the 16th, this hospital has received 144 doses of Pfizer vaccine
.
Anne Zink, chief medical officer of Alaska, said that there are no plans to change the vaccination plan at this time
.
Although the Pfizer vaccine has proven to be safe in clinical trials involving 44,000 people, with an effective rate of about 95%, the Alaska case may exacerbate concerns about possible side effects
.
Experts say that these issues may prompt people to demand stricter guidelines to ensure careful monitoring of adverse reactions
.
(Source: New York Times) The CDC in the United States once stated in a new crown vaccination guidance that people who have a severe allergic reaction to the first shot of the new crown vaccine should not receive a second shot
.
The CDC also stated that after the first batch of new crown vaccines were sent to all states in the United States on the 13th, 272,000 people have been vaccinated across the United States, and 6 people developed severe allergic reactions during the observation period and received timely treatment
.
In response to the public's concern about whether people with a history of allergies can be vaccinated with the new crown vaccine, Wang Huaqing, chief expert of the China Centers for Disease Control and Prevention's immunization program, responded to popular science at the press conference of the Joint Prevention and Control Mechanism of the State Council on September 7, 2021
.
He said: "Regarding the contraindications of vaccination allergies, the "New Coronary Vaccination Technical Guidelines" stipulates two points.
One is allergic to vaccine components; the other is severe allergic reactions to the new crown vaccine in the past
.
There are two kinds of allergies.
It is not possible to get vaccinated
.
People
who have food allergies, drug allergies, cosmetics allergies, and mite allergies can usually be vaccinated
.
” He also said: “It is suspected that allergies are related to vaccination.
Need to determine whether it is a general reaction or an abnormal reaction
.
Every place has a vaccination abnormal response investigation and diagnosis expert group and a vaccination abnormal response identification group, which will make comprehensive judgments based on the characteristics of the vaccine, the clinical manifestations and past history of the recipient, the diagnosis and treatment process, and the vaccination situation, etc.
, to determine whether it is correct or not Allergic reactions caused by vaccination
.
"Regarding the issue of allergies to the new crown vaccine, a recent study by the Stanford University School of Medicine showed that allergic reactions to the new mRNA-based new crown vaccine are rare, usually mild and treatable, and they should not stop people.
vaccination
.
the results of the study on September 17 published in "JAMA Network Open" magazine
.
senior author of the study, NADDISY Foundation pediatric food allergy, and immunology professor, asthma Kari Nadeau, MD, said: "we want to Know the allergens of the new vaccines and understand the causes of them
.
"This study analyzed the 22 potential allergic reactions of the first batch of 39,000 doses of Pfizer and Moderna's new crown vaccine received by the Stanford University health care institution shortly after receiving the emergency use authorization of the U.
S.
Food and Drug Administration (FDA)
.
Most people who responded in the study were allergic to components that help stabilize the new crown vaccine; they did not show allergies to vaccine components that are immune to the SARS-CoV-2 virus
.
In addition, these allergic reactions occur through indirect activation of allergic pathways, which It makes them easier to alleviate than many allergic reactions
.
Nadeau, director of the Sean Parker Center for Allergy and Asthma Research at Stanford University, said: "It's nice to know that these reactions are manageable
.
Allergic reactions to these new vaccines are rare.
If it does happen, there are ways to control it
.
"The lead author of the study is a former postdoctoral scholar, Dr.
Christopher Warren, who is now an assistant professor at Northwestern University's Feinberg School of Medicine
.
Nadeau also said that this study also proposes how vaccine manufacturers can reformulate vaccines to reduce allergic reactions.
Possibility
.
Delivery of protein manufacturing instructions .
The new coronavirus vaccine based on mRNA provides immunity through small fragments of mRNA, which encodes the molecular instructions for protein production
.
Because the mRNA in the vaccine is fragile, it is wrapped in lipids (fatty substances) and sugars.
bubbles in order to maintain stability
.
when the vaccine is injected into a person's arm, mRNA can enter the nearby muscles and immune cells, then produce non-infectious protein similar to SARS-CoV-2 surface of the virus
.
these proteins trigger the immune Reactions enable the human immune system to recognize and resist the virus
.
According to the Federal Vaccine Adverse Event Reporting System, the estimated incidence of severe vaccine-related allergic reactions (severe allergic reactions requiring hospitalization) for Pfizer and Moderna vaccines is per 100 Ten thousand doses of 4.
7 cases and 2.
5 cases
.
However, the federal system did not capture all allergic reactions to the vaccine, and often ignored those mild or moderate allergic reactions
.
In order to fully understand how common the allergic reactions of the new vaccine are, and How serious, the research team checked the medical records of medical workers: between December 18, 2020 and January 26, 2021, they received 38895 doses of mRNA-based COVID-19 vaccine at Stanford Medical School
.
These vaccinations included 31635.
Pfizer vaccine and 7260 doses of Moderna vaccine
.
Researchers searched the medical records of allergic reactions of vaccinators and determined which reactions were related to the vaccine
.
Twenty-two subjects, 20 of whom were women, may have allergic reactions, which means that specific symptoms began to appear within 3 hours of receiving the injection
.
Researchers looked for the following symptoms in the recipient’s medical records: hives; swelling of the mouth, lips, tongue, or throat; shortness of breath, wheezing, or chest tightness; or changes in blood pressure or loss of consciousness
.
Only 17 of 22 subjects met the diagnostic criteria for anaphylaxis
.
Three subjects received adrenaline therapy, usually for stronger allergic reactions
.
All 22 people recovered
.
Among the 22 subjects, 15 had a history of allergic reactions recorded by a doctor, including 10 allergic to antibiotics, 9 allergic to food, and 8 allergic to non-antibiotic drugs
.
(Some recipients have more than one type of allergy
.
) The researchers performed follow-up laboratory tests on 11 people to determine what type of allergic reaction they had and what triggered their allergy: the inertia in the foam Sugar or lipid components, or other components in the vaccine? Study participants underwent a skin prick test in which clinicians injected small amounts of potential allergens-lipids, sugars (polyethylene glycol or polysorbate) or whole vaccines into the skin
.
The skin prick test can detect allergic reactions mediated by an antibody called immunoglobulin E (IgE); these reactions are usually associated with the most severe allergies
.
In the skin prick test, no subject reacted to the inert ingredients in the vaccine, and only one subject's skin reacted to the entire new crown vaccine
.
Subsequent blood tests showed that the vaccinators did not have significant levels of IgE antibodies against the vaccine components
.
Since the skin test cannot explain the mechanism of the receptor's allergic reaction, the researchers proceeded to another diagnostic test
.
Vaccine recipients provided blood samples to test for allergic activation of immune cells called basophils
.
The blood samples of 10 of the 11 participants showed a reaction to polyethylene glycol (PEG), an inert ingredient used in the Pfizer and Moderna vaccines
.
In addition, when the entire mRNA vaccine was mixed with their own basophils, the basophils of all 11 subjects were activated
.
The blood of all 11 subjects contained high levels of anti-PEG IgG antibodies; IgG antibodies in some cases helped to activate basophils.
This finding suggests that these individuals may be susceptible to PEG prior to vaccination.
Sensitive
.
Nadeau said: "It seems that the mRNA itself does not cause allergic reactions
.
" In addition, data shows that the reaction to the new crown vaccine is usually not the most serious allergic reaction, which is good news in terms of vaccine safety
.
Allergic reactions mediated by IgG and basophils can be controlled with antihistamines, fluids, corticosteroids, and close observation, which means that many individuals who respond to the first dose of the vaccine can be safely under medical supervision To receive the second dose of vaccine
.
PEG is widely used as a stabilizer for household products, cosmetics and medicines, and women are more likely to be exposed to large amounts of this substance, which may explain why more vaccine allergies appear among women
.
(Repeated exposure to a substance can sometimes sensitize the immune system and cause allergies
.
) Nadeau said: "Since most of the reactions are to polyethylene glycol PEG rather than the active ingredient of the vaccine, it is very likely that vaccine manufacturers will reformulate the vaccine with different stabilizers, and these stabilizers are unlikely to cause allergies.
.
"references: https: //medicalxpress.
com/news/2021-09-allergies-mrna-based-covid-vaccines-rare.
html Note: This article is intended to introduce the progress of medical research, treatment programs can not be used as a reference
.
If you need health guidance, please go to a regular hospital
.
Popular·Article Gene Sequencing [Nature Sub-Journal] The largest DNAm gene research to date: Research on genetic variant tumors related to DNAm at 420,509 DNAm sites in the blood has been identified [Heavyweight] Scientists at Johns Hopkins University The discovery that the self-correction function of genes can resist blood cancer is expected to be a major breakthrough in the treatment of blood cancer! Genetic testing [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
The new coronavirus [Nature] is a heavyweight! Why can the delta mutant virus spread so quickly and fiercely? Scientists from the University of Cambridge will take you to understand its obesity and health [The Lancet] Be alert! After more than 9 million BMI measurements of more than 2 million people, it is found that young people aged 18 to 24 are at the highest risk of being overweight or obese in the next ten years.
New coronavirus [Nature] The world's first needle-free DNA new coronavirus vaccine is about to be used first in India! According to a survey of 28,000 people, its effectiveness is 67%, and it can even prevent Delta vaccine research [Cell] Have you been vaccinated against HPV? Scientists at Johns Hopkins University have discovered that if they are vaccinated while young, they will be protected from throat cancer and cervical cancer after 25 years.
Intestinal health [Research] "Universal" intestinal microbiota: 40,000 data confirm that antibiotics cause Recommendations for the direct causes of cancer·Activities The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
