JAMA Sub-Journal: 10 times the risk of coronary heart disease! Ten years of follow-up suggest that diabetes is an important risk factor

It is worth noting that women under the age of 55 with type 2 diabetes have a nearly tenfold increased risk of coronary heart disease over the next 20 years, and lipoprotein insulin resistance (LPIR) has been shown to be a powerful predictive biomarker.
study was published recently in JAMA Cardiology.
researchers analyzed about 50 clinical indicators associated with cardiovascular health and biomarkers of lipids, metabolism, inflammation, etc.
found that diabetes at any age was the biggest risk factor for coronary heart disease after adjusting for other potential influences.
risk of developing diabetes under the age of 55 is 10.71 times higher than in non-diabetic populations, and 3.47 times higher risk of coronary heart disease in people aged 75 and older.
risk of coronary heart disease was 10.92 times and 4.49 times higher in non-diabetic people aged 55 to lt;65 and 65 to 75 years, respectively.
Other coronary heart disease risk factors for people under 55 years of age include metabolic syndrome (6.09 times the risk of coronary heart disease), high blood pressure (4.58 times the risk of coronary heart disease), obesity (4.33 times the risk of coronary heart disease) and smoking (3.92 times the risk of coronary heart disease).
Of the nearly 50 biomarkers, LPIR (a new insulin resistance measure) was most significantly associated with coronary heart disease in women under 55 years of age, compared with commonly used measures such as LDL-C (LDL-C, "bad" cholesterol) and glycation of hemoglobin (HbA1c).
LPIR uses a weighted combination of 6 lipoprotein measurements and is analyzed with specialized laboratory tests.
in women under 55, LDL-C was associated with a 40 per cent increased risk of coronary heart disease, while LPIR was associated with a sixfold (600 per cent) increase in risk.
women had a worse prognosm of premature heart events than men. Dr Samia Mora, of Harvard Medical School and co-author of the paper, said:
In other healthy women, insulin resistance, type 2 diabetes and its associated diagnosis, metabolic syndrome are the main contributing factors to premature coronary artery events.
obese women under the age of 55 were about four times more likely to develop coronary artery events, as were women in that age group who smoked, lacked physical activity, had a family history or had high blood pressure.
" researchers acknowledge that the study was limited because it focused on women, with more than 95 percent of the subjects being white.
Mora believes the results may be more significant in other ethnic groups with higher prevalence rates, such as metabolic syndrome, insulin resistance and diabetes.
Mora said: "When a younger person has a cardiovascular event, it affects their future quality of life, productivity and contribution to society.
" so it is important to develop effective interventions as the prevalence of diabetes and its associated risk factors increase dramatically.
"Most diabetes is preventable, but it is a system-wide problem and we urgently need to further study new strategies to improve this outcome and reduce the risk of diabetes."
this may be an innovative lifestyle-based strategy, such as community efforts, broader public health efforts, medically targeted metabolic pathways, or new surgical methods.
" References: s1. Dugani, SB, et al. (2020). Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women. JAMA Cardiology, DOI: 10.1001/jamacardio.2020.7073 [2] Diabetes powerfully associated with premature coronary heart disease in women. Retrieved January 22, 2020, from Note: This article is intended to describe advances in medical and health research, not treatment options recommended.
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