JAMA sub-issue: Top medical institutions confirm that drinking more coffee reduces colorectal cancer deaths and prolongs survival

Written | Edited by Wang Cong | Typesetting by Wang Duoyu | Shui Chengwen On September 17, 2020, Mayo Medical Center, Dana-Farber Cancer Institute and other top international medical research institutions cooperated to publish research papers in the top medical journal JAMA Oncology, Further analysis of data from large clinical trials found that for patients with advanced and metastatic colorectal cancer, those who drank 2-3 cups of coffee a day had longer overall survival and a lower risk of cancer progression, and those who drank 4 cups of coffee a day benefited bigger
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Several studies over the past few years have shown that drinking coffee on a regular basis can provide many health benefits
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One of the notable benefits is that drinking coffee can reduce cancer risk
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Drinking more coffee can reduce the number of deaths due to liver cancer.
In August 2020, several Australian research institutions cooperated and published a paper in the journal Alimentary Pharmacology and Therapeutics [1].
Through the analysis of the global burden of disease dataset, it was shown that with coffee intake The increase in the amount of liver cancer-related mortality worldwide decreases, specifically, if every person in the world drinks at least two cups of coffee a day, the number of deaths due to liver cancer in the world will be reduced by more than 450,000, if every person drinks at least four cups of coffee a day.
A cup of coffee will reduce the number of deaths from liver cancer by more than 720,000
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Drinking more coffee can reduce the risk of various chronic diseases On July 23, 2020, the New England Journal of Medicine (NEJM), the first of the four major medical journals, published a review paper entitled: Coffee, Caffeine, and Health [2]
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The paper pointed out that there is substantial evidence that drinking coffee does not increase the risk of cardiovascular disease and cancer, and drinking 3 to 5 cups of coffee a day is associated with a reduced risk of several chronic diseases
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Drinking more coffee is related to prolonging the life expectancy of colorectal cancer patients On September 17, 2020, the Mayo Medical Center, Dana-Farber Cancer Institute and other top international medical research institutions cooperated in the top medical journal JAMA Oncology.
of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer [3]
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The research team further analyzed observational data from a large clinical trial of colorectal cancer patients and found that among 1,171 patients with metastatic colorectal cancer who received treatment, those who drank 2-3 cups of coffee a day had longer overall survival and cancer.
The risk of exacerbation was lower, and the benefit was greater for patients who drank 4 cups of coffee a day
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The paper's data come from a phase III clinical trial comparing the addition of cetuximab and/or bevacizumab to standard chemotherapy in patients with previously untreated locally advanced or metastatic colorectal cancer
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As part of the clinical trial, the researchers asked these patients about their dietary intake, including coffee intake, through questionnaires
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Data were collected from October 27, 2005, to January 18, 2018, and the researchers correlated the data with information on the progression of the cancer after treatment
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Several compounds in coffee have previously been known to have antioxidant, anti-inflammatory, and potentially cancer-effective properties, and epidemiological studies have found that increased coffee intake is associated with improved survival in patients with advanced colorectal cancer, but it is not yet known.
Evidence for the association between caffeine deprivation and survival in patients with metastatic disease
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The researchers found that patients who drank 2-3 cups of coffee a day had longer overall survival and a lower risk of cancer progression compared to patients who drank no coffee, and those who drank 4 cups a day had greater benefits
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Coffee intake and overall survival in colorectal cancer patients Coffee intake and progression-free survival in colorectal cancer patients The findings could establish a link between coffee drinking and a reduced risk of cancer development and death in colorectal cancer patients, the researchers say However, these data are not sufficient to establish a causal relationship between the two
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 Therefore, it is too early to recommend drinking more coffee as a potential treatment for colorectal cancer, but this study shows that drinking coffee is not only harmless, but likely has many benefits
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In conclusion, the study further supports the importance of diet and other modifiable factors in the treatment of colorectal cancer patients, said the study's corresponding author Kimmie Ng
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Further research is now needed to determine whether there is a causal relationship between coffee intake and improved outcomes in colorectal patients, and which substances in coffee are responsible for this benefit
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Paper links: 1.
https://onlinelibrary.
wiley.
com/doi/full/10.
1111/apt.
160202, https:// https://jamanetwork.
com /journals/jamaoncology/article-abstract/2770262Special reminder: This article only interprets and introduces relevant research progress truthfully, and does not constitute a purchase or use recommendation
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