JAMA: Proper use of antibiotics to fight bacterial infections

, June 8, 2020 /PRNewswire/ -- The increase in bacterial antibiotic resistance --- and the lack of new antibiotics are the current major global health problems associated with bacterial infectionsReducing the use of antibiotics appears to be one of the few ways to maintain their effectiveness and limit the emergence of drug resistance, doctors at the University of Geneva, the University of Lausanne and the University of Vadoy Central Hospital in Switzerland, among others, have tested the possibility of a shorter-term treatment to avoid the consequences of bacterial resistance in a study of more than 500 patients(pictured:their results, published in the journal Journal of the American Medical Association, suggest that a cut in treatment time in half could achieve the same effectIn addition, scientists have shown that adjusting antibiotic treatment regimens to each patient's individual characteristics and disease patterns will further reduce the dose of the drug without losing its effectivenessThis work proposes new proposals to promote the rational use of antibioticsbacterial emis is a blood infection, usually caused by a urinary or lung infection caused by several bacteriaAlthough it is common in older people, it is still serious and must be treated effectively with antibioticsTheteam conducted a large-scale randomized study of 504 patients recruited from three Swiss hospitals between April 2017 and May 2019"We randomly divided the sample into three groups," said Werner Albrich, an infectious disease doctor at StGallen HospitalThe second group received the same antibiotics, but only took them for 7 daysThe third group set the timing of antibiotic use based on the level of inflammation in each patientPierre-Yves Bochud, Professor of infectious diseases atCHUV/UNIL, added: "In addition, our work shows that the dose of treatment can be tailored to each patient, requiring only daily measurements of the amount of CRP in the blood with inflammatory markers "In this study, the scientists immediately stopped treatment in the third group of patients once they found that the level of CRP in the blood dropped by 75 percent from a peak Although they received shorter antibiotic treatment times, their success rate was comparable to that of the other two groups the principle of a 'one size fits all' is becoming increasingly medically incorrect, and by detecting inflammatory biomarkers, it can promote truly personalized treatment while reducing the risk of increased bacterial resistance (Bio Valley Bioon.com) Source: Rational use of antibiotics can help fight bos
big original origins: Dach E V., et al (2020) Effect of The Effect of C-Reactive Protein-Antibiotic-Antibiotic Treatment, 7-Day Day, or 14-Day Treatment on 30
-Day JAMA doi.org/10.1001/jama.2020.6348.