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Although the safety of epidural analgesic (LEA) delivery in newborns has been confirmed, the long-term health effects of LEA on future generations have yet to be studied.
recently assessed the relationship between maternal LEA and the risk of autism spectrum disorder (ASDs) in offspring.
reviewed longitudinal birth cohort study data from population-based clinical birth cohort electronic medical records.
between 1 January 2008 and 31 December 2015, a total of 147,895 vaginal births were attended.
children from the age of 1 until the following conditions occur: ASD clinical diagnosis, final health plan registration, death or study end date December 31, 2018.
results of this study are ASD clinical diagnosis.
ASD risk ratio (HR) associated with LEA exposure was evaluated using Cox proportional risk regression analysis.
of the newborns in the study, 74,425 boys (50.3%), with an average gaternal age of 38.9 weeks at the time of delivery and 109719 (74.2%) receiving LEA.
13,055 mothers (11.9%) in the LEA group and 510 (1.3%) out of 38,176 in the non-LEA group had a fever during childbirth.
2039 children (1.9%) and 485 children (1.3%) in the non-LEA group were diagnosed with autism spectrum disorder.
, the ASD risk ratio for children in the LEA group was 1.37 compared to non-LEA exposure after adjusting for potential confuse factors.
compared to the unexposed group, the risk of ASD was 1.33 for children with LEA exposure of less than 4 hours, 1.35 for children with LEA exposure time of 4-8 hours, and 1.46 for children with LEA exposure time of more than 8 hours.
in the LEA group, the ASD risk was associated with an increase in the duration of LEA exposure (linear trend HR: 1.05 every 4 hours) after adjusting the covariance.
had no significant effect on asD risk associated with LEA exposure.
study suggests that maternal epidural analgesia may be associated with an increased risk of autism spectrum disorders in children.
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