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JAMA Oncol: The longer you are overweight, the higher your risk of colorectal cancer!

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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overweight obesity

hyaluronic acid cancer

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According to WHO estimates, there are at least 300 million obese adults worldwide, and 1.
4 billion are overweight
.

Being overweight is associated with an increased risk of cancer, but the risk may be underestimated because previous studies did not account for cumulative lifetime exposure

colorectal cancer

This study aimed to assess the association of cumulative lifetime overweight with colorectal cancer (CRC) risk
.

This is a population-based case-control study conducted in Germany since 2003, with 5635 CRC patients and 4515 control individuals obtaining his/her height and self-reports from age 20 to current age for 10 years weight
.

Body mass index (BMI) = weight (kg) ÷ height 2 (m2), calculate the BMI of each subject every year since the age of 20, and draw a linear curve graph

Changes in colorectal risk per SD increase in eBMI and WYO

The mean age of CRC patients (n=5635) was 68.
4 years, of which 3366 (59.
7%) were male; the mean age of controls (n=4515) was 68.
5 years, of which 2759 (61.
1%) were male
.

WYO was associated with CRC risk, with an adjusted hazard ratio (OR) fluctuating between 1.

WYO was associated with CRC risk compared with subjects who maintained normal range weight, with adjusted hazard ratio (OR) fluctuations ranging from 1.

The effect of long-term overweight on colorectal cancer risk is significantly higher than that estimated based on BMI measurements at a single time point

Original source:

Li X, Jansen L, Chang-Claude J, Hoffmeister M, Brenner H.

Risk of Colorectal Cancer Associated With Lifetime Excess Weight.
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