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JAMA Oncol: Generic HD201 is as effective as trastuzumab in ERBB2-positive breast cancer!

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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The use of trastuzumab has changed the treatment and prognosis of ERBB2-positive breast cancer

breast cancer

HD201 is a biosimilar of trastuzumab developed by Prestige BioPharma Ltd in Singapore

This is a randomized clinical trial (TROIKA) conducted in 70 medical centers in 12 countries.

diagnostic immunization

Of 502 female patients (mean 53 years) who were randomized to receive HD201 or trastuzumab, 474 (94.

Overall pathological complete response rate in both groups

The overall pathological complete response rates were 45% and 48.

Efficacy analysis in the intention-to-treat population

In conclusion, this randomized trial shows that HD201 is as effective as trastuzumab in the treatment of ERBB2-positive breast cancer

HD201 is comparable to trastuzumab in ERBB2-positive breast cancer HD201 is comparable to trastuzumab in ERBB2-positive breast cancer

Original source:

Xavier Pivot, et al.

Efficacy of HD201 vs Referent Trastuzumab in Patients With ERBB2-Positive Breast Cancer Treated in the Neoadjuvant Setting A Multicenter Phase 3 Randomized Clinical Trial.
JAMA Leaves

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