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Neonatal hypoxic-ischemic encephalopathy (HIE) is still a major public health problem that plagues millions of newborns worldwide, often leading to cerebral palsy, intellectual disability, learning disabilities and death
.
Despite receiving hypothermia treatment, currently 29% of infants continue to have abnormal outcomes between 18 and 22 months of age, so there is still room for optimization of care
Neonatal hypoxic-ischemic encephalopathy (HIE) is still a major public health problem that plagues millions of newborns worldwide, often leading to cerebral palsy, intellectual disability, learning disabilities and death
The rewarming phase is the least studied aspect of the treatment of hypothermia, which can influence or predict the outcome
This pre-designated nested cohort study was registered to participate in the Optimal Cooling (OC) multi-center Eunice Kennedy Shriver National Institute of Child Health and Human Development from December 2011 to December 2013.
NICHD) Infants in the neonatal study network trial were followed up for 2 years, and infants who had been cooled for 72 hours or 120 hours (group A) or 120 hours (group B) were randomly selected
.
The main trial included 364 infants
This pre-designated nested cohort study was registered to participate in the Optimal Cooling (OC) multi-center Eunice Kennedy Shriver National Institute of Child Health and Human Development from December 2011 to December 2013.
Compare the continuous amplitude EEG records of two central amplitude integrated EEG readers 12 hours before rewarming and 12 hours during rewarming to find evidence of EEG seizure activity in the treatment arm and blindness during the rewarming period
The main result was that ECG seizures occurred during the 72 or 120 hours of rewarming, compared to the previous 12 hours
- 120 cases were enrolled neonates (70 males, 58%), 66 cases of group A, group B 54 embodiment
The study found that a higher chance of EEG episodes during rewarming is related to death or disability at the age of 2 years.
Literature source: https://pubmed.
80599.
net/34661629/ https://pubmed.
80599.
net/34661629/ Leave a message here
