JAMA Neurol: The decrease in rapid eye movement sleep is associated with an increase in mortality in middle-aged and older.

!---- In the United States, between 50 and 70 million people are affected by sleep disorders, which are associated with cardiovascular diseases, metabolic diseases, mental illness, and all-cause deaththere has been extensive research on the relationship between sleep disorders and mortality, most studies focus only on the effects of patients' self-reporting of sleep durationsleep can be divided into four stages, the first stage of sleep (N1) usually lasts about 5 minutes, during which eye and body muscle activity slows down, is the most likely to be wokenThe second stage ofsleep (N2) lasts 10 to 25 minutesthe eyeballs stop moving completely and their heart rate and body temperature dropThe third stage (N3) ofsleep is the deep sleep phaseThe fourth stage ofsleep (N4) is the rapid eye movement, REM phasegenerally enters this stage 70 to 90 minutes after falling asleepduring this time, the eyeballs will turn rapidly and their heart rate and blood pressure will riseis known to be associated with poor sleep loss of rapid eye movement (REM) and poor outcomes in physical and mental health, little is known about the relationship between REM sleep (N4) and non-REM sleep phases (N1, N2, and N3) time-by-time and causeof deathis REM sleep deficiency associated with an increasein mortality rate? The cross-sectional study, based on multicenter populations, used data from two queues, The Outcome of Sleep Disorders in the Elderly (MrOS) and the Wisconsin Sleep Queue Study (WSC)the study included 4,050 patients, assuming that the decrease in REM sleep was associated with an increase in death winds, and used MrOS to test the associationrepeated validation in WSC in order to assess the consistency and diffusion of the resultsresults showed that the lack of REM sleep was associated with an increased risk of total death in a cohort study of 2,675 older men who followed up at 12.1 years, the mortality rate increased by 13 percent for every 5 percent reduction in REM the results were validated in another group of 1,375 middle-aged men and women who followed up at 20.8 years this suggests that the decrease in REM sleep is associated with an increased risk of mortality in middle-aged and older people study concluded that there was a strong correlation between the proportion of rapid eye movement sleep and mortality, and that accelerated aging of the brain could lead to a decrease in rapid eye movement sleep, making it a death marker but given the complex biological functions of rapid eye movement sleep, further research is needed on whether there is a causal relationship .