JAMA Neurol: Study of Genetic Risk Factors Related to Parkinson's Disease in Asian Populations

In the European population, large-scale genome-wide association studies have identified 90 risk variants associated with Parkinson's disease (PD), and researchers recently examined PD-related risk genes in Asian populations and compared genetic risk differences in Asian and European populationsresearchers collected PD cases from Singapore, Malaysia, Hong Kong, Taiwan, Chinese mainland and South Korea for genome-wide association data collection, mainly with common variants of genotypes, associations with disease status, and multigene risk scoresin 31,575 samples, including 6,724 PD patients (average age, 64.3 years; age of onset, 58.8 years; 3472 (53.2%) males) and 24,851 control groups (age 59.4 years; 11,030 cases of (45.0%) males)Eleven significant genomicly significant sites were identified, 2 of which were new (SV2C and WBSCR17), and 9 were found in previous European queuesA strong correlation between SV2C was confirmed after validation in European bloodline and Japanese samples, but WBSCR17 showed potential genetic heterogeneityThe multi-gene risk scoring model, which includes the above 11 site variants, showed a significant improvement in the area below the curve (63.1 percent vs 60.2%) compared to the model with only 78 European sitesThe study of PD-related gene risk whole genome associations in asian populations found two new gene sites, as well as nine previously discovered European population sites, which confirmed the similarities and differences in PD genetic risk factors among Asian and European individuals and have potential academic and clinical implications for risk stratification and precision medicine in Asian populations