JAMA Neurol: Circadian rhythm disorder increases Parkinson's risk in older adults

Many older people suffer from circadian rhythm disorder, and researchers recently examined the association between rest activity rhythms (RAR) and the risk of PDthe MrOS Sleep Study recruited 3,135 male participants with 24-hour RAR data (amplitude, meson, robustness, and top phase) of 2,930 patients, with no PD symptoms baselineThe main endpoint of the study was sudden PD, and the relationship between the quartile of RAR parameterand and the risk of PD was analyzed by multivariable logistic regressionThe average age ofparticipants was 76.3 years, and 78 (2.7%) developed PD during 11 years of follow-upAfter considering all covariates, PD risk increases with the reduction of circadian amplitude (rhythm strength) (ratio of 1.77 per 1-SD, the risk increases with the decrease of the meson (1.64 per 1-SD) and increases with the decrease of robustness (OR decreases by 1.54 per 1-SD)For participants with the lowest quarter of RAR amplitude, meson, or robustness, the risk of PD increased by three times compared to the highest quarter of participants with amplitude (OR:3.11), meson (OR: 3.04) and robustness (OR: 2.65)The correlation remained after PD cases that occurred within 2 years of further adjustment of nighttime sleep disorders, duration and exclusion of baselinesThere was no significant correlation between the top phase and PD riskstudies suggest that the decrease in circadian rhythm is associated with an increased risk of PD, suggesting that it may be an important precursor to the occurrence of PD