JAMA Netw Open: No matter how much alcohol is consumed overall, drinking shrap results in a significant increase in an individual's risk of developing dementia.

!--webeditor:page title" -- -- Individuals with alcohol use disorders tend to have a higher risk of developing dementia, and alcohol abuse is a target for successful prevention of dementia, which induces brain atrophy and is accompanied by neuron deficiency, especially Inflammation of the central nervous system, hypoglycemia, epilepsy and depression are all risk factors for dementia, and the effects of alcohol on dementia may be indirect, as evidenced by a variety of diseases associated with dementia, such as liver and kidney disease, diabetes, hypertension, arrhythmics and coronary heart disease.
photo source: Mika Kivimaki, et al, JAMA Netw Open. 2020; 3 (9): e2016084. doi:10.1001/jamanetworkopen.2020.16084 Current research evidence suggests that alcohol consumption as a risk factor for dementia is usually associated with individual alcohol consumption as a whole, but researchers are not aware of the key role that alcohol-induced brain loss plays in the onset of dementia, according to a recent study published in the international journal JAMA Network, entitled "The Association of Alcohol-Induced Loss of Alcohol And Alcohol State. Scientists from Institutions such as University College London have revealed a link between alcohol-induced loss of consciousness and overall alcohol consumption and individual dementia, as well as whether 14 potential alcohol-related diseases, including diabetes, high blood pressure, cardiovascular disease, liver and kidney disease, are linked to alcohol-induced loss of consciousness and dementia events.
the study, researchers studied a total of 131,415 participants from seven cohorts, including the UK, France, Sweden and Finland, with participants aged 18-77 at baseline (1986-2012) and all reporting their drinking At the beginning of the study, when it was not diagnosed with dementia, the researchers followed them for an average of 14.4 years (range: 12.3-30.1 years);
researchers said they used two thresholds to define higher alcohol intake, greater than 14 units per week (U) (UK definition) and more than 21 units (U) (U) (U definition); The risk ratio between U and 1-14 U is 1.16 (95% CI, 0.98-1.37), while the risk ratio between ingesting more than 21 U and 1-21 U per week is 1.22 (95% CI, 1.01-1.48).
of the 95,591 participants who reported alcohol-induced loss of consciousness, 10,004 (10.4%) reported loss of consciousness as a result of alcohol consumption in the past 12 months, respectively, in men (HR, 2.86; A link between loss of consciousness and dementia was found in groups of 95%CI, 1.77-4.63) and women (HR, 2.09; 95% CI, 1.34-3.25).
And the link between alcohol-induced loss of consciousness and dementia may not be explained by the other 14 alcohol-related diseases, the researchers noted, using a reference group of non-unconscious moderate drinkers (1-14 U per week), regardless of whether the participants drank moderate alcohol per week (HR), 2.19; 95% CI, 1.42-3.37) or severe (HR, 2.36; 95% CI, 1.57-3.54), participants who reported losing consciousness after drinking alcohol were twice as likely to develop dementia as the reference group.
photo source: Mika Kivimaki, et al, JAMA Netw Open. 2020;3 (9): e2016084. doi:10.1001/jamanetworkopen.2020.16084 The results of this study show that alcohol-induced loss of consciousness is directly related to an increased risk of dementia in individuals, regardless of overall alcohol consumption.
few studies have been conducted on the link between alcohol-induced loss of consciousness and dementia, and most of the studies are based on small samples.
A previous study of 544 adults found that losing awareness of alcohol-related illness once in the past 12 months increased an individual's risk of dementia by 3.2 times, while alcohol-related loss of consciousness at least twice in the past year increased an individual's risk of dementia by 10 times;
In addition, the researchers found that alcohol-induced loss of consciousness was also associated with the onset of a wide range of neuropathological diseases in the body, including early or late-stage all-cause dementia, Alzheimer's disease, dementia characterized by atherosclerosis cardiovascular disease, and that alcohol was neurotoxic and reached directly into neurons in the brain across the blood-brain barrier. High concentrations of alcohol and its metabolite acetaldehyde can trigger pathological processes that induce brain damage; neurotoxic damage may be caused by the release of large amounts of glutamate, which overst stimulates the brain and damages or kills brain cells by the excitable toxic effects mediated by excess N-methyl-D-tianmenosteine permeable activity.
In this study, researchers also noted a link between alcohol-induced loss of consciousness and dementia among moderate drinkers, supporting the hypothesis that alcohol-induced loss of consciousness may be harmful to brain health, regardless of overall alcohol consumption or alcohol intake.
!--/ewebeditor:page--!--ewebeditor:page-title"--reverse causal association may explain the researchers' findings that if people are not diagnosed with preclinical dementia due to early brain pathological changes It may be more likely to experience or report loss of brain consciousness after drinking alcohol; the short-term association between loss of consciousness and dementia may be consistent with this possibility, and when researchers were excluded from cases of dementia found in follow-up visits over the past 10 years, they suggest that alcohol-induced loss of consciousness may be associated with a twice the risk of dementia in the population.
Finally, the researchers note that this study is the largest to date to analyze the link between alcohol intake and alcohol-induced loss of consciousness and dementia in the population, and the results show that excessive drinking increases the risk of dementia in people by 1.2 times compared to moderate drinking; For participants, regardless of their overall weekly alcohol consumption, their risk of developing dementia was twice that of moderate drinkers (who did not lose consciousness), an increase in the risk that alcohol patterns were also important compared to the overall weekly alcohol consumption, and the findings provided a basis for later scientists to analyze the effects of alcohol abuse on brain health.
() References: Mika Kivimaki, Archana Singh-Manoux, G. David Batty, et al, Association of Alcohol-Induced Loss of Consciousness and Overall Alcohol Alcohol With Risk for Dementia, JAMA Netw Open. 2020; 3 (9): e2016084. doi:10.1001/jamanetworkopen.2020.16084 !--/ewebeditor:page