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High seepage saline is the main method for treating severe symptomatic hyponatrea, which can be divided into chronic persistent infusion (SCI) or intermittent single rapid injection (RIB) therapy, and researchers recently compared the differences in the risk of over-correction of high permeable saline RIB and SCI in patients with symptomatic hyponatreaemia.
This study included 178 patients older than 18 years of age with moderate to severe hyponanamicemia with blood sugar-corrected sodium sodium (sNa) levels of 125mmol/L or less.
patients were randomly treated with 3% highly permeable salt water RIB or SCI for 24 to 48 hours, layered according to the severity of clinical symptoms.
result of this study is excessive correction at any given time, defined as an increase in sNa levels of more than 12 or 18 mmol/L in 24 hours or 48 hours, measured every 6 hours.
178 patients, with an average age of 73.1 years, 80 men (44.9%) with an average sNa concentration of 118.2mmol/L, randomly divided into RIB group (n=87) or SCI group (n=91).
15 out of 87 patients in the RIB group (17.2%) and 22 of the 91 patients in the SCI group (24.2%) experienced excessive correction (absolute risk difference: -6.9%).
compared to the SCI group, the risk of re-treatment in the RIB group was lower (36 cases (41.4%)vs 52 cases (57.1%); the absolute risk difference was -5.8%).
there was no difference between the two groups in terms of increased sNa concentration and improved symptoms, but ribs achieved a higher proportion of clinical correction targets within 1 hour (32.2% vs 17.6%) than SCI, with no significant difference in endpoints between the groups.
research believes that chronic continuous infusion or intermittent single quick injection treatment of high seepage salt water is effective and safe, there is no significant difference in the risk of over-correction, but the treatment rate after intermittent single quick injection is low, and the correction rate is high within 1 hour, it is recommended that high seepage salt water intermittent single fast injection as the preferred treatment for symptomatic hyponatreaemia.
