-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Electrical spinal cord stimulation (SCS) is mainly used to treat intractable pain, such as postoperative pain syndrome, phantom limb pain, central pain, etc.
, its annual global market size growth rate of more than 8%, is expected to reach 2.
8 billion US dollars in 2025, but its clinical effect is full of controversy
.
It is estimated that 500,000 patients worldwide are currently treated with spinal cord stimulation each year, and one of the most common indications is persistent nerve root pain
after lumbar spine surgery.
Epidemiological studies have shown that about 30% of patients with degenerative spinal disease do not achieve the desired results after surgery, and residual or worsening pain after spinal surgery is more difficult to treat
.
The principle of SCS is to place electrodes at the back of the epidural space of the patient's spinal canal, and electrical impulses are transmitted through the electrodes to stimulate the conduction tract of the posterior spinal column and the posterior horn sensory neurons, resulting in a tingling sensation that is easily tolerated and can replace the sensation
of pain.
Spinal cord burst stimulation can control pain while eliminating irritation and improving patient tolerance
.
Researchers have recently investigated the efficacy
of high-frequency stimulation therapy in the treatment of chronic nerve root pain after surgery for degenerative lumbar spine diseases.
The study was conducted at St.
Olaves University Hospital in Norway and enrolled 50 patients, in which patients were randomized to receive high-frequency stimulation for 3 months, followed by simulated stimulation for 3 months, and 2 courses were conducted with a pulse frequency of 40Hz
in the stimulation unit.
The primary endpoint of the study was patient-reported Oswestry disability index (ODI; range, 0 points [no disability] to 100 points [maximum disability]; The minimum clinically important difference was 10 points) score change
.
Secondary outcomes were leg and back pain, quality of life, level of physical activity, and adverse events
.
The mean age of patients was 52.
2 years, and there were 27 women, of whom 47 (94%) received at least one follow-up ODI score and 42 (84%) patients completed all studies
.
The mean ODI score at baseline was 44.
7 points, the mean ODI change was −10.
6 points during stimulation, and −9.
3 points during the placebo control period, with a difference between groups of −1.
3 points, which did not reach the minimum clinically important difference
predetermined.
There was no significant difference
between groups in secondary outcomes.
Nine patients (18%) experienced adverse events, of which four (8%) required surgical revision of the implanted system
.
It was concluded that for patients with chronic nerve root pain after surgery for degenerative lumbar spine disease, high-frequency stimulation therapy had no significant effect
on improving pain.
Original source:
Sozaburo Hara et al.
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery A Randomized Clinical Trial，JAMA，October 18, 2022.
