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Duchenne muscular dystrophy (DMD), a neuromuscular disease caused by mutations in the MIM*300377 gene, is the most common neuromuscular disease in children , with an incidence of approximately 1 in 5,000 to 6,000 boys
.
Corticosteroids, such as prednisone and deflazacort, increase muscle strength and function in people with DMD
.
Children's researchers compared the efficacy and adverse events of three of the most common corticosteroid regimens in boys with DMD
The study included 196 boys aged 4-7 years with DMD who had not previously received corticosteroid medication and were randomized to receive daily prednisone (0.
75 mg/kg, n = 65), daily deflazacort ( 0.
The average age of the patients was 5.
8 years, and 164 completed the study
.
Compared with intermittent prednisone therapy, daily prednisone and daily deflazacort regimens were more effective in improving the primary endpoint, the difference between the 2 daily regimens was not significant, and the difference was mainly due to the difference in the speed of foot lift (Daily Prednisone vs Intermittent Prednisone Difference: 0.
06 rise/s; Daily Deficit vs Intermittent Prednisone Difference: 0.
Differences are mainly due to differences in foot lift speed (daily prednisone vs intermittent prednisone difference: 0.
Influence of different programs on the speed of foot-lifting in children
The study concluded that for children with Duchenne muscular dystrophy, daily prednisone and daily deflazacort regimens were superior to intermittent prednisone regimens in improving motor function, lung function, and treatment satisfaction
.
.
For children with Duchenne muscular dystrophy, daily prednisone and daily deflazacort regimens were superior to intermittent prednisone regimens in improving motor function, lung function, and treatment satisfaction
.
Original source:
Michela Guglieri et al.
Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy A Randomized Clinical Trial.
Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy A Randomized Clinical Trial.
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