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JAMA Dermatol: Prevalence, incidence and cancer risk in patients with psoriasis and psoriatic arthritis

 Last Update: 2022-01-23
 Source: Internet
 Author: User

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The current relationship between psoriasis and cancer risk remains open to debate
.

A study published today in JAMA Dermatol assessed cancer associations and risk in patients with psoriasis or psoriatic arthritis, including the risk of specific cancer subtypes

JAMA

We screened two databases (PubMed and Embase) for relevant literature as of January 1, 2019, and included observational cohort studies that included populations of patients with psoriasis or psoriatic arthritis
.

Research must be original and report on the incidence or prevalence of cancer in this population

The search showed that a total of 365 studies were included in the full-text evaluation
.

Due to the heterogeneity of the included studies, a random effects model was used

The results of the analysis showed that the overall cancer prevalence of psoriasis patients was 4.
78% (95% CI, 4.
02%-5.
59%), the incidence rate was 11.
75/1000 person-years (95% CI, 8.
66-15.
31), and the hazard ratio (RR) was 1.
21 (95% CI, 1.
11-1.
33)
.

There were several increased risks of cancer, including keratinocyte carcinoma (RR, 2.

lymphoma lung cancer

Taken together, the findings of the study suggest that patients with psoriasis appear to have a slightly increased risk of cancer, particularly keratinocyte carcinoma and lymphoma
.

Data on biologic therapy did not show an increased risk of cancer

Original source:

Sofie Vaengebjerg, et al.

Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis

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