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JAMA: Continuous hypertonic fluid therapy is not beneficial to neurological function improvement in patients with traumatic brain injury

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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It is estimated that 69 million people worldwide experienced traumatic brain injury (TBI) of various causes in 2019.

Prevention Recently, researchers have investigated the effect of continuous injection of hypertonic saline on the neurological prognosis of patients with traumatic brain injury at 6 months.

The COBI study was carried out in 9 intensive care centers in France.

The average age of the patients was 44 years, 77 (20.

At 6 months, the adjusted odds ratio (OR) of the GOS-E scores between the groups was 1.

Improvement of neurological function and death risk assessment between groups

In patients with moderate to severe traumatic brain injury, continuous infusion of 20% hypertonic saline treatment has no significant difference in neurological improvement at 6 months compared with standard treatment.

Original source

Antoine Roquilly et al.

com/journals/jama/article-abstract/2780326" target="_blank" rel="noopener">Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury The COBI Randomized Clinical Trial.
JAMA

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