JAMA: A systematic review and meta-analysis of the relationship between hypothyroidism and clinical depression

Background: Hypothyroidism is considered a cause of depression or an important risk factor, but recent studies have provided conflicting evidence regarding the existence and extent of this association
.

Data source: From the creation of the pubmed, PsycINFO and Embase databases to May 2020, we searched for research on the association between hypothyroidism and clinical depression
.

Research selection: The two reviewers independently selected epidemiological and population-based studies, which provide a statistical classification of laboratory or international diseases and related health problems, and are based on operational standards (such as the "Manual of Psychiatric Diagnosis and Statistics" 》) Diagnosis of hypothyroidism and diagnosis of depression (the international statistical classification of diseases or diseases and related health problems) or the cut-off value in the established rating scale
.

Data extraction and analysis: Two reviewers independently extracted data and evaluated the research based on the Newcastle-Ottawa scale
.

Main results and measures: The pre-determined main result is the relationship between clinical depression and hypothyroidism or autoimmunity
.

Results: Among the 4350 articles screened, 25 studies were selected for meta-analysis, including 348,014 participants
.

Table 1 The relationship between hypothyroidism and depression

Table 2 Main results

Table 3 The relationship between thyroid peroxidase antibody positive and depression

Conclusion and significance: In this systematic review and meta-analysis, the effect size between hypothyroidism and clinical depression is much lower than previously assumed, and the mild association may be limited to overt hypothyroidism and female individuals
.

Bode H, Ivens B, Bschor T, Schwarzer G, Henssler J, Baethge C, Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis.